Protonix I.V. (Pantoprazole Sodium) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 8, 2012

Protonix IV

Peptic Ulcer »

What is a peptic ulcer?

A peptic ulcer is a hole in the gut lining of the stomach, duodenum, or esophagus. A peptic ulcer of the stomach is called a gastric ulcer; of the duodenum, a duodenal ulcer; and of the esophagus, an esophageal ulcer. An ulcer occurs when the lining of these organs is corroded by the acidic digestive juices which are secreted by the stomach cells. Peptic ulcer disease is common, affecting millions of Americans yearly. The medical cost of treating peptic ulcer and its complications runs in the billions of dollars annually. Recent medical advances have increased our understanding of ulcer formation. Improved and expanded treatment options are now available.

What are the causes of peptic ulcers?

For many years, excess acid was believed to be the major cause of ulcer disease. Accordingly, treatment emphasis was on neutra...

Read the Peptic Ulcer article »

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PROTONIX® I.V.
(pantoprazole sodium)

DRUG DESCRIPTION

Therapeutic class: Proton Pump Inhibitor (PPI)

Route of administration: For Intravenous use only The active ingredient in PROTONIX® I.V. (intravenous pantoprazole sodium) for Injection is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C₁₆H₁₄F₂N₃NaO₄S, with a molecular weight of 405.4. The structural formula is:

PROTONIX® I.V. (pantoprazole sodium) Structural Formula Illustration

Pantoprazole sodium is a white to off-white crystalline powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The stability of the compound in aqueous solution is pH-dependent. The rate of degradation increases with decreasing pH. The reconstituted solution of PROTONIX I.V. for Injection is in the pH range 9.0 to 10.5.

PROTONIX I.V. for Injection is supplied as a freeze-dried powder in a clear glass vial fitted with a rubber stopper and crimp seal containing pantoprazole sodium, equivalent to 40 mg of pantoprazole, edetate disodium (1 mg), and sodium hydroxide to adjust pH.