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home > drugs a-z list > protonix i.v. (pantoprazole sodium) drug center > protonix i.v. (pantoprazole sodium) drug - overdosage and contraindications
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Protonix IV
What are antacids, and how do they work?
Antacids are a class of drugs used to treat conditions caused by the acid that is produced by the stomach. The stomach naturally secretes an acid called hydrochloric acid that helps to break down proteins. This acid causes the contents of the stomach to be acidic in nature, with a pH level of 2 or 3. (pH levels are a measure of acidity in the stomach: the lower the number, the greater the acidity.) The stomach, duodenum, and esophagus are protected from acid by several protective mechanisms. When there is too much acid or protective mechanisms are inadequate, the lining of the stomach, duodenum or esophagus may become damaged by the acid, giving rise to various gastrointestinal symptoms such as abdominal pain, heartburn (due to gastroesophageal reflux disease or GERD), and other gastro-esophageal symptoms.
Antacids reduce acidity by neutralizing (counteracting) acid, reducing the acidity in the stomac...
Protonix I.V.
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OVERDOSE
Experience in patients taking very high doses of pantoprazole ( > 240 mg) is limited. Adverse events seen in spontaneous reports of overdose generally reflect the known safety profile of pantoprazole.
Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive.
Single intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor.
CONTRAINDICATIONS
PROTONIX is contraindicated in patients with known hypersensitivity reactions including anaphylaxis to the formulation [see WARNINGS AND PRECAUTIONS] or any substituted benzimidazole.
Last reviewed on RxList: 12/28/2011
This monograph has been modified to include the generic and brand name in many instances.
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