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Experience in patients taking very high doses of pantoprazole ( > 240 mg) is limited. Adverse events seen in spontaneous reports of overdose generally reflect the known safety profile of pantoprazole.
Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive.
Single intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor.
Last reviewed on RxList: 3/3/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Protonix I.V. Information
- Protonix I.V. Drug Interactions Center: pantoprazole iv
- Protonix I.V. Side Effects Center
- Protonix I.V. FDA Approved Prescribing Information including Dosage
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