Protonix I.V. (Pantoprazole Sodium) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Protonix IV

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What are antacids, and how do they work?

Antacids are a class of drugs used to treat conditions caused by the acid that is produced by the stomach. The stomach naturally secretes an acid called hydrochloric acid that helps to break down proteins. This acid causes the contents of the stomach to be acidic in nature, with a pH level of 2 or 3. (pH levels are a measure of acidity in the stomach: the lower the number, the greater the acidity.) The stomach, duodenum, and esophagus are protected from acid by several protective mechanisms. When there is too much acid or protective mechanisms are inadequate, the lining of the stomach, duodenum or esophagus may become damaged by the acid, giving rise to various gastrointestinal symptoms such as abdominal pain, heartburn (due to gastroesophageal reflux disease or GERD), and other gastro-esophageal symptoms.

Antacids reduce acidity by neutralizing (counteracting) acid, reducing the acidity in the stomac...

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Protonix I.V.

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PROTONIX® I.V.
(pantoprazole sodium)

DRUG DESCRIPTION

Therapeutic class: Proton Pump Inhibitor (PPI)

Route of administration: For Intravenous use only The active ingredient in PROTONIX® I.V. (intravenous pantoprazole sodium) for Injection is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole, a compound that inhibits gastric acid secretion. Its empirical formula is C₁₆H₁₄F₂N₃NaO₄S, with a molecular weight of 405.4. The structural formula is:

PROTONIX® I.V. (pantoprazole sodium) Structural Formula Illustration

Pantoprazole sodium is a white to off-white crystalline powder and is racemic. Pantoprazole has weakly basic and acidic properties. Pantoprazole sodium is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane. The stability of the compound in aqueous solution is pH-dependent. The rate of degradation increases with decreasing pH. The reconstituted solution of PROTONIX I.V. for Injection is in the pH range 9.0 to 10.5.

PROTONIX I.V. for Injection is supplied as a freeze-dried powder in a clear glass vial fitted with a rubber stopper and crimp seal containing pantoprazole sodium, equivalent to 40 mg of pantoprazole, edetate disodium (1 mg), and sodium hydroxide to adjust pH.

Last reviewed on RxList: 12/28/2011
This monograph has been modified to include the generic and brand name in many instances.