"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
Manifestations of Overdosage
Observed in normal subjects only: dizziness, blurred vision, diplopia, headache, impaired accommodation, nausea, slight tachycardia. In therapy it has been difficult to differentiate side effects due to the drug from those due to the effects of the poison.
There are no known absolute contraindications for the use of PROTOPAM (see PRECAUTIONS: DRUG INTERACTIONS and DOSAGE AND ADMINISTRATION). Relative contraindications include known hypersensitivity to the drug and other situations in which the risk of its use clearly outweighs possible benefit.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 10/13/2010
Additional Protopam Information
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