"The U.S. Food and Drug Administration announced today that injectable drugs used in total parenteral nutrition (TPN) in critical shortage will be imported into the United States and available to patients this week.
TPN is an intravenous"...
Protopam Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Protopam (pralidoxime chloride) is used as an antidote to treat poisoning by a pesticide or by a drug used to treat a muscle disorder. It is not effective as an antidote for all types of pesticide poisonings. It is a cholinesterase reactivator that reverses muscle weakness or paralysis caused by a poison or certain drug overdose. Common side effects include pain where the medicine was injected, blurred vision, feeling dizzy or drowsy, headache, or nausea.
Protopam is given as an intravenous infusion under physician supervision. The initial dose is 1000 to 2000 mg, preferably as an infusion in 100 mL of normal saline, over a 15- to 30-minute period. Protopam may interact with atropine, reserpine, chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, or trifluperazine. Tell your doctor all medications and supplements you use. During pregnancy, Protopam should be used only if prescribed. It may be harmful to a fetus. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.
Our Protopam (pralidoxime chloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Protopam in Detail - Patient Information: Side Effects
Some of the side effects of pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- fast heart rate;
- rapid breathing;
- increased muscle stiffness;
- a choking feeling;
Less serious side effects may include:
- pain where the medicine was injected;
- blurred vision;
- feeling dizzy or drowsy;
- headache; or
Read the entire detailed patient monograph for Protopam (Pralidoxime Chloride)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Protopam FDA Prescribing Information: Side Effects
Forty to 60 minutes after intramuscular injection, mild to moderate pain may be experienced at the site of injection.
Pralidoxime chloride may cause blurred vision, diplopia and impaired accommodation, dizziness, headache, drowsiness, nausea, tachycardia, increased systolic and diastolic blood pressure, hyperventilation, and muscular weakness when given parenterally to normal volunteers who have not been exposed to anticholinesterase poisons. In patients, it is very difficult to differentiate the toxic effects produced by atropine or the organophosphate compounds from those of the drug.
Elevations in SGOT and/or SGPT enzyme levels were observed in 1 of 6 normal volunteers given 1200 mg of pralidoxime chloride intramuscularly, and in 4 of 6 volunteers given 1800 mg intramuscularly. Levels returned to normal in about 2 weeks. Transient elevations in creatine phosphokinase were observed in all normal volunteers given the drug.
When atropine and pralidoxime chloride are used together, the signs of atropinization may occur earlier than might be expected when atropine is used alone. This is especially true if the total dose of atropine has been large and the administration of pralidoxime chloride has been delayed. Excitement and manic behavior immediately following recovery of consciousness have been reported in several cases. However, similar behavior has occurred in cases of organophosphate poisoning that were not treated with pralidoxime chloride.
Drug Abuse And Dependence
PROTOPAM (pralidoxime chloride) is not subject to abuse and possesses no known potential for dependence.
Read the entire FDA prescribing information for Protopam (Pralidoxime Chloride)
Additional Protopam Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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