December 2, 2015
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Overdosage of estrogen plus progestin therapy may cause nausea and vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of CE plus MPA together with institution of appropriate symptomatic care.


PROVERA is contraindicated in women with any of the following conditions:

  1. Undiagnosed abnormal genital bleeding.
  2. Known, suspected, or history of breast cancer.
  3. Known or suspected estrogen-or progesterone-dependent neoplasia.
  4. Active DVT, PE, or a history of these conditions
  5. Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions.
  6. Known anaphylactic reaction or angioedema to PROVERA.
  7. Known liver impairment or disease.
  8. Known or suspected pregnancy.
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 5/26/2015


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