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Overdosage of estrogen plus progestin therapy may cause nausea and vomiting, breast tenderness, dizziness, abdominal pain, drowsiness/fatigue and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of CE/MPA together with institution of appropriate symptomatic care.

PROVERA (medroxyprogesterone acetate tablets) should not be used in women with any of the following conditions:

1. Undiagnosed abnormal genital bleeding
2. Known, suspected, or history of cancer of the breast
3. Known or suspected estrogen- or progesterone-dependent neoplasia
4. Active deep vein thrombosis, pulmonary embolism or a history of these conditions
5. Active or recent (within the past year) arterial thromboembolic disease (for example, stroke and myocardial infarction)
6. Known liver dysfunction or disease
7. Missed abortion
8. As a diagnostic test for pregnancy
9. Known hypersensitivity to the ingredients in PROVERA (medroxyprogesterone acetate tablets) tablets
10. Known or suspected pregnancy.

Last reviewed on RxList: 4/9/2008
This monograph has been modified to include the generic and brand name in many instances.