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In this Article

• What is modafinil (Provigil)?
• What are the possible side effects of modafinil (Provigil)?
• What is the most important information I should know about modafinil (Provigil)?
• What should I discuss with my health care provider before taking modafinil (Provigil)?
• How should I take modafinil (Provigil)?
• What happens if I miss a dose (Provigil)?
• What happens if I overdose (Provigil)?
• What should I avoid while taking modafinil (Provigil)?
• What other drugs will affect modafinil (Provigil)?
• Where can I get more information?

What happens if I miss a dose (Provigil)?

Take the missed dose as soon as you remember, but avoid taking the medication if you do not plan to be awake for several hours. If it is close to your normal bedtime hour, you may need to skip the missed dose and wait until the next day to take the medicine again.

Talk with your doctor about what to do if you miss a dose of modafinil. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Provigil)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling excited or agitated, confusion, trouble sleeping, nausea, or diarrhea.

What should I avoid while taking modafinil (Provigil)?

Modafinil affects the central nervous system. This can cause effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid other dangerous activity until you know how this medication will affect your level of wakefulness.

Avoid drinking alcohol while taking modafinil.

What other drugs will affect modafinil (Provigil)?

Before using modafinil, tell your doctor if you are using any of the following drugs:

• cyclosporine (Neoral, Sandimmune, Gengraf);
• propranolol (Inderal);
• rifampin (Rifadin, Rimactane, Rifater);
• a sedative such as diazepam (Valium), midazolam (Versed), or triazolam (Halcion);
• antifungal medications such as itraconazole (Sporanox) or ketoconazole (Nizoral);
• seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton);
• antidepressants such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others; or
• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

This list is not complete and there may be other drugs that can interact with modafinil. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about modafinil.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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