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Provocholine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Provocholine (methacholine chloride) is a cholinergic drug that causes wheezing and shortness of breath and is used as a test to determine whether you may have asthma. It is only administered in a clinical setting and is used for testing, and not to treat any conditions. Common side effects include headache, sore throat, lightheadedness, nausea, vomiting, or dizziness.
Before Provocholine inhalation challenge is begun, baseline pulmonary function tests must be performed. The dose needed for testing will be determined by your physician. Provocholine may interact with beta-blockers or asthma drugs. Tell your doctor all medications and supplements you use. During pregnancy, Provocholine should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.
Our Provocholine (methacholine chloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Provocholine Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these serious side effects occur: trouble breathing, cough, wheezing, chest pain/tightness, irregular heartbeat.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Provocholine (Methacholine Chloride)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Provocholine FDA Prescribing Information: Side Effects
Adverse reactions associated with 153 inhaled methacholine chloride challenges include one occurrence each of headache, throat irritation, Iightheadedness and itching.
Provocholine® (methacholine chloride powder for inhalation) is to be administered only by inhalation. When administered orally or by injection, methacholine chloride is reported to be associated with nausea and vomiting, substernal pain or pressure, hypotension, fainting and transient complete heart block. (See OVERDOSAGE.)
Read the entire FDA prescribing information for Provocholine (Methacholine Chloride)
Additional Provocholine Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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