April 29, 2017
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Pseudoephedrine

Medical and Pharmacy Editor:

Brand Name: Sudafed, Nexafed, Zephrex-D

Generic Name: pseudoephedrine

Drug Class: Decongestants, Systemic

What Is Pseudoephedrine and How Does It Work?

Pseudoephedrine temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies, and nasal congestion associated with sinusitis. Pseudoephedrine also temporarily relieves sinus congestion and pressure.

Pseudoephedrine is available under the following different brand names: Sudafed, Nexafed, and Zephrex-D.

Dosages of Pseudoephedrine:

Dosage Forms and Strengths

Tablet, immediate-release

  • 30 mg
  • 60 mg
  • 120 mg

Tablet, extended-release

  • 120 mg
  • 240 mg

Tablet, IMPEDE technology (Nexafed)

  • 30 mg
  • IMPEDE technology utilizes an advanced polymer matrix to limit extraction of pseudoephedrine from tablets and deter methamphetamine manufacturing

    Tablet, TAREX technology (Zephrex-D)

  • 30 mg
  • TAREX technology utilizes an advanced polymer matrix to limit extraction of pseudoephedrine from tablets and deter methamphetamine manufacturing

Syrup

  • 3 mg/mL

Dosage Considerations – Should be Given as Follows:

Nasal Congestion

  • Adult, immediate release: 60 mg orally every 4-6 hours as needed
  • Adult, extended release: 120 mg orally every 12 hours or 240 mg orally every 24 hours
  • Children under 2 years: Safety and efficacy not established
  • Children 2-6 years: 5-30 mg orally every 4-6 hours as needed
  • Children 6-12 years: 30 mg orally every 4-6 hours, OR 4 mg/kg/day divided every 6 hours; not to exceed 120 mg/day
  • Children over 12 years: 60 mg orally every 6 hours as needed (immediate release); alternatively, 120 mg orally every 12 hours (extended release) or 240 mg orally every 24 hours (extended release)

Dosing Considerations

  • Potential toxic dose children under 6 years: 11 mg/kg

Priapism (Off-label), Adult

  • 60-120 mg orally
Medically Reviewed by a Doctor on 4/11/2017



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