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Pseudovent 400

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Pseudovent 400 Capsules

CLINICAL PHARMACOLOGY

Pseudoephedrine hydrochloride is an oral sympathomimetic amine which acts predominantly by a direct action on alpha(a)-adrenergic receptors. Clinically, pseudoephedrine shrinks swollen mucus membranes, reduces tissue hyperemia, edema, and nasal congestion; and increases nasal airway patency. Pseudoepherine has been shown to have a mean elimination half-life of 4-6 hours, which is dependent on urine pH.

Guaifenesin is an expectorant which increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions. By reducing the viscosity of secretions, guaifenesin increases the efficiency of the cough reflex and of ciliary action in removing accumulated secretions from the trachea and bronchi. Guaifenesin is readily absorbed from the gastrointestinal tract and is rapidly metabolized and excreted in the urine. Guaifenesin has a plasma half-life of one hour. The major urinary metabolite is β - (2 - methoxyphenoxy) lactic acid.

As a result of these drugs, sinus and bronchial drainage is improved, and dry, nonproductive coughs become more productive and less frequent.

Last reviewed on RxList: 3/24/2008
This monograph has been modified to include the generic and brand name in many instances.

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