Pulmicort Turbuhaler (Budesonide) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

Pulmicort Turbuhaler

Asthma Complexities »

Unusual symptoms of asthma

Patients suffering from episodes of asthma do not always have the typical symptoms of asthma such as shortness of breath, chest tightness, and wheezing (symptoms of airway narrowing). Instead, patients can have symptoms that may not appear to be related to asthma. These "unusual" asthma symptoms include

rapid breathing,
sighing,
fatigue and inability to exercise properly,
difficulty sleeping,
anxiety and difficulty concentrating,
chronic cough without wheezing,
protracted cough after an upper respiratory illness,
recurrent diagnosis of walking pneumonia, and
noises emanating from the chest usual during exhalation.

To complicate matters, symptoms of asthma are not consistent and often vary from time to time in an individual. In some patients, symptoms are influenced by diurnal factor...

Read the Asthma Complexities article »

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PULMICORT TURBUHALER®
(budesonide) Inhalation Powder 200 mcg

For Oral Inhalation Only.

DRUG DESCRIPTION

Budesonide, the active component of PULMICORT TURBUHALER (budesonide) 200 mcg, is a corticosteroid designated chemically as (RS)-11β, 16α, 17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde. Budesonide is provided as a mixture of two epimers (22R and 22S). The empirical formula of budesonide is C₂₅H₃₄O₆ and its molecular weight is 430.5. Its structural formula is:

Pulmicort Turbuhaler (Budesonide) structural formula illustration

Budesonide is a white to off-white, tasteless, odorless powder that is practically insoluble in water and in heptane, sparingly soluble in ethanol, and freely soluble in chloroform. Its partition coefficient between octanol and water at pH 7.4 is 1.6 x 10³.

PULMICORT TURBUHALER (budesonide) is an inhalation-driven multi-dose dry powder inhaler that contains only micronized budesonide. Each actuation of PULMICORT TURBUHALER provides 200 mcg budesonide per metered dose, which delivers approximately 160 mcg budesonide from the mouthpiece (based on in vitro testing at 60 L/min for 2 sec).

In vitro testing has shown that the dose delivery for PULMICORT TURBUHALER (budesonide) is substantially dependent on airflow through the device. Patient factors such as inspiratory flow rates will also affect the dose delivered to the lungs of patients in actual use (see Patient's Instructions for Use). In adult patients with asthma (mean FEV₁ 2.9 L [0.8 - 5.1 L]) mean peak inspiratory flow (PIF) through PULMICORT TURBUHALER (budesonide) was 78 (40-111) L/min. Similar results (mean PIF 82 [43-125] L/min) were obtained in asthmatic children (6 to 15 years, mean FEV₁ 2.1 L [0.9 - 5.4 L]). Patients should be carefully instructed on the use of this drug product to assure optimal dose delivery.

Last reviewed on RxList: 9/11/2007
This monograph has been modified to include the generic and brand name in many instances.