In this Article

• What is dornase alfa (Pulmozyme)?
• What are the possible side effects of dornase alfa (Pulmozyme)?
• What is the most important information I should know about dornase alfa (Pulmozyme)?
• What should I discuss with my healthcare provider before using dornase alfa (Pulmozyme)?
• How should I use dornase alfa (Pulmozyme)?
• What happens if I miss a dose (Pulmozyme)?
• What happens if I overdose (Pulmozyme)?
• What should I avoid while using dornase alfa (Pulmozyme)?
• What other drugs will affect dornase alfa (Pulmozyme)?
• Where can I get more information?

What should I discuss with my healthcare provider before using dornase alfa (Pulmozyme)?

Do not use dornase alfa if you have had an allergic reaction to it or to other Chinese Hamster Ovary cell products.

Before using dornase alfa, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines. You may require a dosage adjustment or special monitoring during your treatment.

Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether dornase alfa passes into breast milk. Do not use dornase alfa without first talking to your doctor if you are breast-feeding a baby.

How should I use dornase alfa (Pulmozyme)?

Use dornase alfa exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Dornase alfa is administered by inhalation using a recommended nebulizer. Your doctor or other healthcare provider will give you detailed instructions on the use and maintenance of the nebulizer.

Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.

If you are also taking other respiratory medications, use them in the order directed by your doctor (e.g., a bronchodilator, followed by chest physiotherapy, then dornase alfa, etc.) Do not dilute or mix dornase alfa with other agents in the nebulizer at the same time.

Ampules of dornase alfa do not contain a preservative. It is intended for one-time use only. Once opened, the entire contents of the ampule must be used or discarded.

Do not use any dornase alfa solution that is cloudy or discolored. Throw away any unused dornase alfa on the expiration date stamped on the ampule.

Dornase alfa should be used on a regular basis to get the most benefit.

Dornase alfa must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Dornase alfa should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours.