home > drugs a-z list > pylera capsules (bismuth subcitrate potassium) drug center > pylera capsules (bismuth subcitrate potassium) drug - medication guide and patient information

• Each dose of PYLERA™ includes 3 capsules. Each dose of all 3 capsules should be taken 4 times a day, after meals and at bedtime for 10 days. Patients should be instructed to swallow the PYLERA™ capsules (bismuth subcitrate potassium) whole with a full glass of water (8 ounces). One omeprazole 20 mg capsule should be taken twice a day with PYLERA™ after the morning and evening meal for 10 days.

Daily Dosing Schedule for PYLERA™ and Omeprazole:

• Administration of adequate amounts of fluid, particularly with the bedtime dose of PYLERA™, is recommended to reduce the risk of esophageal irritation and ulceration, which can be associated with tetracycline hydrochloride.
• Concurrent use of tetracyclines may render oral contraceptives less effective. Patients should be advised to use a different or additional form of contraception. Breakthrough bleeding has been reported. Women who become pregnant while taking PYLERA™, which contains tetracycline hydrochloride, should be advised to notify their prescriber immediately. (See CONTRAINDICATIONS and WARNINGS)
• Patients taking PYLERA™, which contains tetracycline hydrochloride, should be cautioned to avoid exposure to sun or sun lamps. (See WARNINGS)
• Alcoholic beverages should be avoided while taking PYLERA™, which contains metronidazole, and for at least one day afterward. (See DRUG INTERACTIONS)
• Bismuth subcitrate potassium, contained in PYLERA™, may cause temporary and harmless darkening of the tongue and/or black stool. Stool darkening should not be confused with melena (blood in the stool).
• Missed doses can be made up by continuing the normal dosing schedule until the medication is gone. Patients should not take double doses. If more than 4 doses are missed, the prescriber should be contacted.

Last reviewed on RxList: 6/13/2007
This monograph has been modified to include the generic and brand name in many instances.