Pyrazinamide (Pyrazinamide) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

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Pyrazinamide

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PYRAZINAMIDE
Tablets USP 500 mg

DRUG DESCRIPTION

Pyrazinamide, the pyrazine analogue of nicotinamide, is an anti-tuberculous agent. It is a white crystalline powder, stable at room temperature, and sparingly soluble in water. Pyrazinamide has the following structural formula:

C₅H₅N₃O M.W. 123.11

Pyrazinamide Structural Formula Illustration

Each pyrazinamide tablet for oral administration contains 500 mg of pyrazinamide and the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, dibasic calcium phosphate (dihydrate), microcrystalline cellulose, and stearic acid.

What are the possible side effects of pyrazinamide ()?

If you experience any of the following serious side effects, stop taking pyrazinamide and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
a fever;
unusual weakness or fatigue;
nausea, vomiting, or loss of appetite;
yellow skin or eyes;
dark urine;
difficult or painful urination;
painful or swollen joints;

Read All Potential Side Effects and See Pictures of Pyrazinamide »

What are the precautions when taking pyrazinamide (Pyrazinamide)?

Before taking pyrazinamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, gout, high uric acid level in the blood, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Alcohol may increase the risk of liver disease. Avoid alcoholic beverages while using this medication.

Pyrazinamide may cause live bacterial vaccines...

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Last reviewed on RxList: 12/3/2008
This monograph has been modified to include the generic and brand name in many instances.