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Overdosage experience is limited. In one case report of overdose, abnormal liver function tests developed. These spontaneously reverted to normal when the drug was stopped. Clinical monitoring and supportive therapy should be employed. Pyrazinamide is dialyzable.13


Pyrazinamide is contraindicated in persons: with severe hepatic damage; who have shown hypersensitivity to it; with acute gout.


13. Stamathakis G, Montes C, Trouvin JH, et al. Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure. Clinical Nephrology. 1988 ; 30 : 230-234.

Last reviewed on RxList: 12/3/2008
This monograph has been modified to include the generic and brand name in many instances.


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