May 26, 2017
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Pyrazinamide Patient Information Including Side Effects

Brand Names:

Generic Name: pyrazinamide (Pronunciation: peer a ZIN a mide)

What is pyrazinamide ?

Pyrazinamide is an antibiotic. The exact way that pyrazinamide works is unknown.

Pyrazinamide is used to treat tuberculosis (TB).

Pyrazinamide may also be used for purposes other than those listed in this medication guide.

Pyrazinamide 500 mg

elliptical, white, imprinted with P 36, LL

Pyrazinamide 500 mg-VER

round, white, imprinted with VP 012

What are the possible side effects of pyrazinamide ?

If you experience any of the following serious side effects, stop taking pyrazinamide and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
  • a fever;
  • unusual weakness or fatigue;
  • nausea, vomiting, or loss of appetite;
  • yellow skin or eyes;
  • dark urine;
  • difficult or painful urination;
  • painful or swollen joints;
  • worsening gout; or
  • a rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the Pyrazinamide (pyrazinamide) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about pyrazinamide ?

Take all of the pyrazinamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Call your doctor immediately if you experience a fever, loss of appetite, nausea and vomiting, painful or swollen joints, yellowing of your skin or eyes, or darkening of your urine.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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