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Pyrazinamide Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Pyrazinamide is an antibiotic used to treat tuberculosis (TB). Pyrazinamide is available in generic form. Common side effects of pyrazinamide include nausea, upset stomach, vomiting, loss of appetite, mild muscle/joint pain, or fatigue.
The usual dose of Pyrazinamide is 15 to 30 mg/kg once daily, taken orally. It should always be administered with other effective anti-tuberculosis drugs. It is administered for the initial 2 months of a 6-month or longer treatment regimen for drug-susceptible patients. Pyrazinamide may interact with allopurinol, or Acetest and Ketostix urine tests for ketones. Other drugs may interact with pyrazinamide. Tell your doctor all prescription or over-the-counter medicines and supplements you use. During pregnancy, Pyrazinamide should be used only when prescribed. This medication passes into breast milk but the effect on a nursing infant is unknown. Consult your doctor before breastfeeding.
Our Pyrazinamide Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Pyrazinamide in Detail - Patient Information: Side Effects
If you experience any of the following serious side effects, stop taking pyrazinamide and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- a fever;
- unusual weakness or fatigue;
- nausea, vomiting, or loss of appetite;
- yellow skin or eyes;
- dark urine;
- difficult or painful urination;
- painful or swollen joints;
- worsening gout; or
- a rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Pyrazinamide (Pyrazinamide)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Pyrazinamide Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: symptoms of liver disease (such as persistent nausea/vomiting, unusual tiredness/weakness, severe stomach/abdominal pain, yellowing eyes/skin, dark urine), painful/swollen joints.
Tell your doctor immediately if any of these rare but serious side effects occur: change in the amount of urine, easy bleeding/bruising, fast heartbeat.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Pyrazinamide (Pyrazinamide)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Pyrazinamide FDA Prescribing Information: Side Effects
Gastrointestinal: The principal adverse effect is a hepatic reaction (see WARNINGS). Hepatotoxicity appears to be dose related, and may appear at any time during therapy. Gl disturbances including nausea, vomiting and anorexia have also been reported.
Hematologic and Lymphatic: Thrombocytopenia and sideroblastic anemia with erythroid hyperplasia, vacuolation of erythrocytes and increased serum iron concentration have occurred rarely with this drug. Adverse effects on blood clotting mechanisms have also been rarely reported.
Other: Mild arthralgia and myalgia have been reported frequently. Hypersensitivity reactions including rashes, urticaria, and pruritis have been reported. Fever, acne, photosensitivity, porphyria, dysuria and interstitial nephritis have been reported rarely.
Read the entire FDA prescribing information for Pyrazinamide (Pyrazinamide)
Additional Pyrazinamide Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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