Pyridium (Phenazopyridine) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Urinary Tract Infection (UTI In Adults) »

Urinary tract infection (UTI) facts

Urinary tract infections (UTIs) are infections of the urethra, bladder, ureters, or the kidneys, which comprise the urinary tract.
E. coli bacteria cause the majority of UTIs, but many other bacteria, fungi, and parasites may also cause UTIs.
Females have a higher risk for UTIs than most males, probably because of their anatomy; other risk factors for UTIs include any condition that may impede urine flow (e.g., enlarged prostate, congenital urinary tract abnormalities, and inflammation). Patients with catheters or those who undergo urinary surgery and men with enlarged prostates are at higher risk for UTIs.
Symptoms and signs of UTI vary somewhat depending on sex, age, and the area of the urinary tract that is infected; some unique symptoms develop depending on the infecting agent.
UTIs are diagnosed usually by isolating and identifying the urinary pathogen from the patient; there a...

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OVERDOSE

Exceeding the recommended dose in patients with good renal function or administering the usual dose to patients with impaired renal function (common in elderly patients), may lead to increased serum levels and toxic reactions. Methemoglobinemia generally follows a massive, acute overdose. Methylene blue, 1 to 2 mg/kg body weight intravenously, should cause prompt reduction of the methemoglobinemia and disappearance of the cyanosis which is an aid in diagnosis. Oxidative Heinz body hemolytic anemia may also occur, and "bite cells" (degmacytes) may be present in a chronic overdosage situation. Red blood cell G-6-PD deficiency may predispose to hemolysis. Renal and hepatic impairment and occasional failure, usually due to hypersensitivity, may also occur.

CONTRAINDICATIONS

Phenazopyridine Hydrochloride should not be used in patients who have previously exhibited hypersensitivity to it. The use of Phenazopyridine Hydrochloride is contraindicated in patients with renal insufficiency.

Last reviewed on RxList: 8/22/2007
This monograph has been modified to include the generic and brand name in many instances.