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(quinine sulfate) Capsules, USP
QUALAQUIN® use for the treatment or prevention of nocturnal leg cramps may result in serious and life-threatening hematologic reactions, including thrombocytopenia and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP). Chronic renal impairment associated with the development of TTP has been reported. The risk associated with QUALAQUIN use in the absence of evidence of its effectiveness in the treatment or prevention of nocturnal leg cramps outweighs any potential benefit [see WARNINGS AND PRECAUTIONS].
QUALAQUIN (quinine sulfate) is a cinchona alkaloid chemically described as cinchonan-9-ol, 6'-methoxy-, (8&apha;, 9R)-, sulfate (2:1) (salt), dihydrate with a molecular formula of (C20H24N2O2)2•H2SO4•2H2O and a molecular weight of 782.96.
The structural formula of quinine sulfate is:
Quinine sulfate occurs as a white, crystalline powder that darkens on exposure to light. It is odorless and has a persistent very bitter taste. It is only slightly soluble in water, alcohol, chloroform, and ether.
QUALAQUIN is supplied for oral administration as capsules containing 324 mg of the active ingredient quinine sulfate USP, equivalent to 269 mg free base. Inactive ingredients: corn starch, magnesium stearate, and talc.
What are the possible side effects of quinine (Qualaquin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using quinine and call your doctor at once if you have any of these serious side effects:
- fever, chills, confusion, weakness, sweating;
- severe vomiting, stomach pain, diarrhea;
- problems with vision or hearing;
- chest pain, trouble breathing, severe dizziness, fainting, fast or pounding heartbeats;
- severe flushing (warmth, redness, or tingly feeling);
- urinating less than...
What are the precautions when taking quinine sulfate capsules (Qualaquin)?
Before taking quinine, tell your doctor or pharmacist if you are allergic to it; or to quinidine or mefloquine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: previous serious side effects with quinine (such as blood problems), family/personal history of a certain enzyme problem (glucose-6-phosphate dehydrogenase deficiency-G6PD), a certain eye nerve problem (optic neuritis), hearing problems (such as ringing in the ears), a certain nerve/muscle disease (myasthenia gravis), heart rhythm problems (such as atrial fibrillation/flutter), kidney problems,...
Last reviewed on RxList: 7/18/2014
This monograph has been modified to include the generic and brand name in many instances.
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