Quinidine Gluconate (Quinidine Gluconate) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Quinidine Gluconate

Palpitations »

What are palpitations?

Palpitations are unpleasant sensations of irregular and/or forceful beating of the heart. Some persons with palpitations have no heart disease or abnormal heart rhythms and the reasons for their palpitations are unknown. In others, palpitations result from abnormal heart rhythms (arrhythmias).

Arrhythmias refer to heartbeats that are too slow, too rapid, irregular, or too early.
Rapid arrhythmias (greater than 100 beats per minute) are called tachycardias.
Slow arrhythmias (slower than 60 beats per minute) are called bradycardias.
Irregular heart rhythms are called fibrillations (as in atrial fibrillation).
When a single heartbeat occurs earlier than normal, it is called a premature contraction, and this can cause the sensation of a forceful heartbeat.
Abnormalities in the atria, the ventricles, and the elect...

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Quinidine Gluconate

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Quinidine Gluconate
Extended-Release Tablets

DRUG DESCRIPTION

Quinidine is an antimalarial schizonticide and an antiarrhythmic agent with Class Ia activity; it is the d-isomer of quinine, and its molecular weight is 324.43. Quinidine gluconate is the gluconate salt of quinidine; its chemical name is cinchonan-9-ol, 6'-methoxy-, (9S)-, mono-D-gluconate. The structural formula is represented below:

Quinidine Gluconate Structural Formula Illustration

Quinidine gluconate contains 62.3% of the anhydrous quinidine alkaloid, whereas quinidine sulfate contains 82.86%. In prescribing Quinidine Gluconate Extended-release Tablets, this factor should be considered.

Each tablet, for oral administration, contains 324 mg of quinidine gluconate (202 mg of quinidine base) in a matrix to provide extended-release.

Quinidine Gluconate Extended-release Tablets contain the following inactive ingredients: carnauba wax, ethylcellulose, magnesium stearate and povidone.

This product meets USP Drug Release Test 1.

What are the precautions when taking quinidine gluconate (Quinidine Gluconate)?

Before taking quinidine, tell your doctor or pharmacist if you are allergic to it; or to quinine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain types of heart disease (e.g., incomplete or complete heart block without an artificial pacemaker, torsades-type irregular heartbeats, digitalis toxicity), very low blood pressure, history of easy bruising/bleeding (thrombocytopenic purpura) with use of quinine or quinidine, severe muscle weakness (myasthenia gravis).

Before using this medication,...

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Last reviewed on RxList: 10/7/2008
This monograph has been modified to include the generic and brand name in many instances.