Quinidine Injection (Quinidine Gluconate Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Quinidine Injection

Atrial Fibrillation »

What is atrial fibrillation?

Atrial fibrillation (AF) is the most common, abnormal rhythm of the heart.

The heart contracts (beats) and pumps blood with a regular rhythm, for example, at a rate of 60 beats per minute there is a beat every second. The heart may beat faster or slower with a shorter or longer interval between beats, but at any one rate the interval between beats is constant. This regular rhythm occurs as a result of regular electrical discharges (currents) that travel through the heart and cause the muscle of the heart to contract. In atrial fibrillation, the electrical discharges are irregular and rapid and, as a result, the heart beats irregularly and, usually, rapidly.

Atrial fibrillation is common; half a million new cases are diagnosed yearly in the U.S., and billions of dollars are spent annually on its diagnosis and treatment.

What causes atrial fibrillation?

Normal function of the he...

Read the Atrial Fibrillation article »

Quinidine Injection

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QUINIDINE GLUCONATE
(quinidine gluconate (quinidine gluconate (quinidine gluconate injection) injection) ) Injection

DRUG DESCRIPTION

Quinidine is an antimalarial schizonticide and an antiarrhythmic agent with class 1a activity; it is the d–isomer of quinine and its molecular weight is 324.43. Quinidine gluconate (quinidine gluconate (quinidine gluconate injection) injection) is the gluconate salt of quinidine; its chemical name is cinchonan–9–ol, 6'– methoxy–, (9S)–, mono–D–gluconate; its structural formula is

Quinidine Gluconate Structural Formula Illustration

its empirical formula is C₂₀H₂₄N₂O₂•C₆H₁₂O₇, and its molecular weight is 520.58, of which 62.3% is quinidine base.

Each vial of Quinidine Gluconate Injection contains 800 mg (1.5 mmol) of quinidine gluconate (quinidine gluconate (quinidine gluconate injection) injection) (500 mg of quinidine) in 10 mL of Sterile Water for Injection, 0.005% of edetate disodium, 0.25% phenol, and (as needed) D–gluconic acid d–lactone to adjust the pH.

Last reviewed on RxList: 5/21/2009
This monograph has been modified to include the generic and brand name in many instances.