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(levofloxacin) Ophthalmic Solution
QUIXIN® (levofloxacin ophthalmic solution) 0.5% is a sterile topical ophthalmic solution. Levofloxacin is a fluoroquinolone antibacterial active against a broad spectrum of Gram-positive and Gram-negative ocular pathogens. Levofloxacin is a fluorinated 4-quinolone containing a six-member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure. Levofloxacin is the pure (-)-(S)-enantiomer of the racemic drug substance, ofloxacin. It is more soluble in water at neutral pH than ofloxacin.
C18H20FN3O4 •½H2O Mol Wt 370.38
Chemical Name: (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate. Levofloxacin (hemihydrate) is a yellowish-white crystalline powder.
Each mL of QUIXIN® contains 5.12 mg of levofloxacin hemihydrate equivalent to 5 mg levofloxacin.
Contains: Active: Levofloxacin 0.5% (5 mg/mL); Preservative: benzalkonium chloride 0.005%; Inactives: sodium chloride and water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH to approximately 6.5. UIXIN® solution is isotonic with an osmolality of approximately 300 mOsm/kg.
What are the possible side effects of levofloxacin ophthalmic (Quixin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- drainage or crusting of your eye;
- severe eye irritation after using the eye drops;
- feeling like there is something in your eye;
- vision problems, increased light sensitivity;
- eye redness or swelling; or
- fever, or any signs of a new infection.
Less serious side effects may...
What are the precautions when taking levofloxacin ophthalmic solution 0.5% (Quixin)?
Before using levofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, norfloxacin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.
After you apply this drug, your vision may become temporarily blurred or unstable. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.
During pregnancy, this medication should be used only...
Last reviewed on RxList: 12/19/2014
This monograph has been modified to include the generic and brand name in many instances.
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