Quixin (Levofloxacin Ophthalmic Solution 0.5%) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 27, 2012

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Quixin

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QUIXIN®
(levofloxacin) Ophthalmic Solution 0.5%

DRUG DESCRIPTION

QUIXIN® (levofloxacin ophthalmic solution) 0.5% is a sterile topical ophthalmic solution. Levofloxacin is a fluoroquinolone antibacterial active against a broad spectrum of Gram-positive and Gram-negative ocular pathogens. Levofloxacin is the pure (-)-(S)-enantiomer of the racemic drug substance, ofloxacin. It is more soluble in water at neutral pH than ofloxacin.

Structural Formula

Levofloxacin hemihydrate
C₁₈H₂₀FN₃O₄•½H₂O Mol Weight 370.38

Chemical Name:

(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate.

Levofloxacin (hemihydrate) is a yellowish-white crystalline powder.

Each mL of QUIXIN® contains 5.12 mg of levofloxacin hemihydrate equivalent to 5 mg levofloxacin.

Contains:

Active: Levofloxacin 0.5% (5 mg/mL); Preservative: benzalkonium chloride 0.005%; Inactives: sodium chloride and water. May also contain hydrochloric acid and/or sodium hydroxide to adjust pH.

QUIXIN® (levofloxacin ophthalmic solution 0.5%) solution is isotonic and formulated at pH 6.5 with an osmolality of approximately 300 mOsm/kg. Levofloxacin is a fluorinated 4-quinolone containing a six-member (pyridobenzoxazine) ring from positions 1 to 8 of the basic ring structure.

What are the possible side effects of levofloxacin ophthalmic (Quixin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

drainage or crusting of your eye;
severe eye irritation after using the eye drops;
feeling like there is something in your eye;
vision problems, increased light sensitivity;
eye redness or swelling; or
fever, or any signs of a new...

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What are the precautions when taking levofloxacin ophthalmic solution 0.5% (Quixin)?

Before using levofloxacin, tell your doctor or pharmacist if you are allergic to it; or to other quinolone antibiotics (e.g., ciprofloxacin, norfloxacin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems.

After you apply this drug, your vision may become temporarily blurred or unstable. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

During pregnancy, this medication should be used only...

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Last reviewed on RxList: 12/18/2008
This monograph has been modified to include the generic and brand name in many instances.