R-Gene 10

CLINICAL PHARMACOLOGY

Intravenous infusion of R-Gene® 10 (arginine hydrochloride injection) often induces a pronounced rise in the plasma level of human growth hormone (HGH) in subjects with intact pituitary function. This rise is usually diminished or absent in patients with impairment of this function.

Expected Plasma Levels of HGH in ng/mL

Patient Control Range Peak Response to Arginine
Normal 0-6 10-30
Pituitary deficient 0-4 0-10

These ranges are based on the mean values of plasma HGH levels calculated from the data of several clinical investigators and reflect their experiences with various methods of radioimmunoassay. Upon gaining experience with this diagnostic test, each clinician will establish his/her own ranges for control and peak levels of HGH.

L-arginine is a normal metabolite in animals and man and has a low order of toxicity.

Last reviewed on RxList: 2/11/2010
This monograph has been modified to include the generic and brand name in many instances.

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