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This drug should not be used with the following medications because very serious interactions may occur: drugs that strongly affect the removal of ranolazine from your body (including azole antifungals such as itraconazole/ketoconazole, macrolide antibiotics such as clarithromycin, HIV protease inhibitors such as ritonavir, rifamycins such as rifampin, St. John's wort, drugs used to treat seizures such as carbamazepine/phenytoin).

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting ranolazine.

Many drugs besides ranolazine may affect the heart rhythm (QT prolongation), including amiodarone, pimozide, dofetilide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using ranolazine, report all medications you are currently using to your doctor or pharmacist.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other drugs that affect the removal of ranolazine from your body (e.g., aprepitant, cyclosporine, diltiazem, erythromycin, fluconazole, verapamil).

Ranolazine can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include digoxin, trazodone, tricyclic antidepressants (such as amitriptyline, imipramine), certain antipsychotics (such as clozapine, haloperidol, risperidone), among others.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include: severe dizziness/fainting, fast/irregular/very slow heartbeat, confusion.

NOTES: Do not share this medication with others.

Laboratory and/or medical tests (e.g., blood pressure, electrocardiograms) may be performed from time to time to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

Information last revised July 2009 Copyright(c) 2009 First DataBank, Inc.