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Ranexa

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Ranexa

Indications
Dosage
How Supplied

INDICATIONS

RANEXA® is indicated for the treatment of chronic angina.

RANEXA may be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers.

DOSAGE AND ADMINISTRATION

Dosing Information

Initiate RANEXA dosing at 500 mg twice daily and increase to 1000 mg twice daily, as needed, based on clinical symptoms. Take RANEXA with or without meals. Swallow RANEXA tablets whole; do not crush, break, or chew.

The maximum recommended daily dose of RANEXA is 1000 mg twice daily.

If a dose of RANEXA is missed, take the prescribed dose at the next scheduled time; do not double the next dose.

Dose Modification

Dose adjustments may be needed when RANEXA is taken in combination with certain other drugs [see DRUG INTERACTIONS]. Limit the maximum dose of RANEXA to 500 mg twice daily in patients on moderate CYP3A inhibitors such as diltiazem, verapamil, and erythromycin. Use of RANEXA with strong CYP3A inhibitors is contraindicated [see CONTRAINDICATIONS, DRUG INTERACTIONS]. Use of P-gp inhibitors, such as cyclosporine, may increase exposure to RANEXA. Titrate RANEXA based on clinical response [see DRUG INTERACTIONS].

HOW SUPPLIED

Dosage Forms And Strengths

RANEXA is supplied as film-coated, oblong-shaped, extended-release tablets in the following strengths:

  • 500 mg tablets are light orange, with GSI500 on one side
  • 1000 mg tablets are pale yellow, with GSI1000 on one side

Storage And Handling

RANEXA is supplied as film-coated, oblong-shaped, extended-release tablets in the following strengths:

  • 500 mg tablets are light orange, with GSI500 on one side
  • 1000 mg tablets are pale yellow, with GSI1000 on one side

RANEXA (ranolazine) extended-release tablets are available in:

  Strength NDC
Unit-of-Use Bottle (60 Tablets) 500 mg 61958-1003-1
Unit-of-Use Bottle (60 Tablets) 1000 mg 61958-1004-1

Store RANEXA tablets at 25 °C (77 °F) with excursions permitted to 15 ° to 30 °C (59 ° to 86 °F).

Manufactured for: Gilead Sciences, Inc. Foster City, CA 94404. Issued November 2013

Last reviewed on RxList: 11/25/2013
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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