"Male twin Vietnam veterans with post-traumatic stress disorder (PTSD) were more than twice as likely as those without PTSD to develop heart disease during a 13-year period, according to a study supported by the National Institutes of Health."...
High oral doses of ranolazine produce dose-related increases in dizziness, nausea, and vomiting. High intravenous exposure also produces diplopia, paresthesia, confusion, and syncope. In addition to general supportive measures, continuous ECG monitoring may be warranted in the event of overdose. Severe tremor, unsteady gait/incoordination, dysphasia, and hallucinations have been reported in cases of overdose with RANEXA.
Since ranolazine is about 62% bound to plasma proteins, hemodialysis is unlikely to be effective in clearing ranolazine.
RANEXA is contraindicated in patients:
- Taking strong inhibitors of CYP3A [see DRUG INTERACTIONS]
- Taking inducers of CYP3A [see DRUG INTERACTIONS]
- With liver cirrhosis [see Use in Specific Populations]
Last reviewed on RxList: 11/25/2013
This monograph has been modified to include the generic and brand name in many instances.
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