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High oral doses of ranolazine produce dose-related increases in dizziness, nausea, and vomiting. High intravenous exposure also produces diplopia, paresthesia, confusion, and syncope. In addition to general supportive measures, continuous ECG monitoring may be warranted in the event of overdose.
Since ranolazine is about 62% bound to plasma proteins, hemodialysis is unlikely to be effective in clearing ranolazine.
Ranexa is contraindicated in patients:
- Taking strong inhibitors of CYP3A [see DRUG INTERACTIONS]
- Taking inducers of CYP3A [see DRUG INTERACTIONS]
- With liver cirrhosis [see Use In Specific Populations]
Last reviewed on RxList: 8/6/2012
This monograph has been modified to include the generic and brand name in many instances.
Additional Ranexa Information
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