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home > drugs a-z list > ranexa (ranolazine) drug center > ranexa (ranolazine) drug - overdosage and contraindications
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Ranexa
Angina facts
- Angina is one of many causes of chest pain.
- Angina is chest pain that is a result of inadequate oxygen supply to the heart muscle.
- Angina can be caused by coronary artery disease or spasm of the coronary arteries.
- Electrocardiogram (ECG or EKG), exercise stress test, stress echocardiography, stress thallium, and cardiac catheterization are important in the diagnosis of angina.
- Treatment of angina includes rest, medications, angioplasty, and/or coronary artery bypass surgery.
Introduction to angina
Angina is one of the serious causes of chest pain. “Angina” is an abbreviation of angina pectoris, a Latin term for “squeezing of the chest.” Chest pain is a common symptom caused by many different conditions. Some causes require prompt medical attention, such as angina, heart attack, blood clots i...
Ranexa
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OVERDOSE
High oral doses of ranolazine produce dose-related increases in dizziness, nausea, and vomiting. High intravenous exposure also produces diplopia, paresthesia, confusion, and syncope. In addition to general supportive measures, continuous ECG monitoring may be warranted in the event of overdose.
Since ranolazine is about 62% bound to plasma proteins, hemodialysis is unlikely to be effective in clearing ranolazine.
CONTRAINDICATIONS
Ranexa is contraindicated in patients:
- Taking strong inhibitors of CYP3A [see DRUG INTERACTIONS]
- Taking inducers of CYP3A [see DRUG INTERACTIONS]
- With liver cirrhosis [see Use In Specific Populations]
Last reviewed on RxList: 1/12/2012
This monograph has been modified to include the generic and brand name in many instances.
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