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In this Article

• What is ranolazine (Ranexa)?
• What are the possible side effects of ranolazine (Ranexa)?
• What is the most important information I should know about ranolazine (Ranexa)?
• What should I discuss with my health care provider before taking ranolazine (Ranexa)?
• How should I take ranolazine (Ranexa)?
• What happens if I miss a dose (Ranexa)?
• What happens if I overdose (Ranexa)?
• What should I avoid while taking ranolazine (Ranexa)?
• What other drugs will affect ranolazine (Ranexa)?
• Where can I get more information?

What happens if I miss a dose (Ranexa)?

If you miss a dose or forget to take your medicine, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Ranexa)?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose can cause nausea, vomiting, numbness or tingling, dizziness, blurred vision, confusion, or fainting.

What should I avoid while taking ranolazine (Ranexa)?

Ranolazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Grapefruit and grapefruit juice may interact with ranolazine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

What other drugs will affect ranolazine (Ranexa)?

Many drugs can interact with ranolazine. Below is just a partial list. Tell your doctor if you are using:

• aprepitant (Emend);
• cyclosporine (Neoral, Sandimmune, Gengraf);
• digoxin (Lanoxin);
• diltiazem (Cartia, Cardizem) or verapamil (Verelan, Calan, Isoptin, Covera);
• seizure medicine such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin);
• simvastatin (Zocor);
• St. John's wort;
• an antibiotic such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E-Mycin, E.E.S., Ery-Tab), rifabutin (Mycobutin), rifampin (Rifadin, Rifamate), or rifapentin (Priftin);
• an antifungal medication such as fluconazole (Diflucan); itraconazole (Sporanox), or ketoconazole (Nizoral);
• an antidepressant such as amitriptyline (Elavil), doxepin (Adapin, Sinequan), nortriptyline (Aventyl, Pamelor), imipramine (Tofranil), or paroxetine (Paxil);
• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
• medicine to treat a mental illness, such as thioridazine (Mellaril), ziprasidone (Geodon);
• heart rhythm medicine such as amiodarone (Cordarone, Pacerone), quinidine (Cardioquin, Quinidex, Quinaglute), dofetilide (Tikosyn), sotalol (Betapace, Sorine); or
• HIV medicines such as tipranavir (Aptivus), indinavir (Crixivan), saquinavir (Invirase, Fortovase), lopinavir/ritonavir (Kaletra), fosamprenavir (Lexiva), ritonavir (Norvir), atazanavir (Reyataz), or nelfinavir (Viracept).

This list is not complete and there may be other drugs that can interact with ranolazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about ranolazine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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