Rapamune (Sirolimus) Drug Center: Guide to Drug Information for Professionals, Patients and Caregivers at RxList

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May 27, 2012

Rapamune

Kidney Failure »

What are the kidneys?

The kidneys play key roles in body function, not only by filtering the blood and getting rid of waste products, but also by balancing levels of electrolyte levels in the body, controlling blood pressure, and stimulating the production of red blood cells.

The kidneys are located in the abdomen toward the back, normally one on each side of the spine. They get their blood supply through the renal arteries directly from the aorta and send blood back to the heart via the renal veins to the vena cava. (The term "renal" is derived from the Latin name for kidney.)

The kidneys have the ability to monitor the amount of body fluid, the concentrations of electrolytes like sodium and potassium, and the acid-base balance of the body. They filter waste products of body metabolism, like urea from protein metabolism and uric acid from DNA breakdown. Two waste products in the blood can be measured: blood urea nitrogen (BUN) ...

Read the Kidney Failure article »

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Rapamune Drug Center

Medical Editor: John P. Cunha, DO, FACOEP

Prescribing Information

For Patients

Rapamune (sirolimus) is used to prevent your body from rejecting a transplanted kidney. Rapamune is sometimes used in a combination treatment with cyclosporine and a steroid medicine such as prednisone. It is an immunosuppressive agent. Common side effects include diarrhea, joint pain, shaking, acne, or trouble sleeping.

Rapamune is taken orally once daily, and the initial dose should be given as soon as possible after transplantation. Dose depends on the patient's immunologic risk, among other factors. Rapamune may interact with amphotericin B, bromocriptine, cimetidine, cisapride, danazol, metoclopramide, rifampin, rifabutin, rifapentine, St. John's wort, tacrolimus, ACE inhibitors, antibiotics, antifungal medications, calcium channel blockers, or HIV medicines. Tell your doctor all medications you are taking. Rapamune is not recommended for use during pregnancy. It is recommended that men and women using this medication use two forms of birth control (e.g., condoms and birth control pills) before starting this medication, while taking this medication, and for 12 weeks after stopping this medication. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Breast-feeding is not recommended while using this drug.

Our Rapamune (sirolimus) Drug Center provides a comprehensive view of available drug information as well as related drugs, user reviews, supplements, and diseases and conditions articles.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Rapamune Prescribing Information: Indications & Dosage

RAPAMUNE (sirolimus) Structural Formula Illustration

Prophylaxis of Organ Rejection in Renal Transplantation

Rapamune (sirolimus) is indicated for the prophylaxis of organ rejection in patients aged 13 years or older receiving renal transplants. Therapeutic drug monitoring is recommended for all patients receiving Rapamune (sirolimus) [see DOSAGE AND ADMINISTRATION, WARNINGS AND PRECAUTIONS].

In patients at low- to moderate-immunologic risk, it is recommended that Rapamune (sirolimus) be used initially in a regimen with cyclosporine and corticosteroids; cyclosporine should be withdrawn 2...

Read the complete drug monograph for Rapamune »

What is Rapamune Prescribing Information?

Drug Description - Indications & Dosage - Side Effects & Drug Interactions - Warnings & Precautions - Contraindications - Medication Guide and More

What is Patient information?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Rapamune Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

fast heart rate;
pain when you breathe, feeling short of breath;
chest pain, feeling weak or tired;
coughing up blood or mucus;
feeling like you might pass out;
pale skin, easy bruising or bleeding, weakness;
fever, chills, body aches, flu symptoms;
night ...

Read the complete patient information for Rapamune »

What is Rapamune Patient Information?

Possible Side Effects - Images - What Is - How Should I Take It - What If I Miss a Dose - What Should I Avoid and More

What is Consumer information?

A concise overview of the drug for the patient or caregiver from First DataBank.

Rapamune Consumer Information: Uses

Sirolimus is used with other medications to prevent rejection of a kidney transplant. This medication belongs to a class of drugs known as immunosuppressants. It works by weakening your body's defense system (immune system) to help your body accept the new organ as if it were your own.

HOW TO USE: Read the Medication Guide provided by your pharmacist before you start taking sirolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth, usually once daily or as directed by your do...

Read the complete consumer information for Rapamune »