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home > drugs a-z list > rapamune (sirolimus) drug center > rapamune (sirolimus) drug - overdosage and contraindications
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Rapamune
What are the kidneys?
The kidneys play key roles in body function, not only by filtering the blood and getting rid of waste products, but also by balancing levels of electrolyte levels in the body, controlling blood pressure, and stimulating the production of red blood cells.
The kidneys are located in the abdomen toward the back, normally one on each side of the spine. They get their blood supply through the renal arteries directly from the aorta and send blood back to the heart via the renal veins to the vena cava. (The term "renal" is derived from the Latin name for kidney.)
The kidneys have the ability to monitor the amount of body fluid, the concentrations of electrolytes like sodium and potassium, and the acid-base balance of the body. They filter waste products of body metabolism, like urea from protein metabolism and uric acid from DNA breakdown. Two waste products in the blood can be measured: blood urea nitrogen (BUN) ...
Rapamune
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OVERDOSE
Reports of overdose with Rapamune (sirolimus) have been received; however, experience has been limited. In general, the adverse effects of overdose are consistent with those listed in the adverse reactions section [see ADVERSE REACTIONS].
General supportive measures should be followed in all cases of overdose. Based on the low aqueous solubility and high erythrocyte and plasma protein binding of sirolimus, it is anticipated that sirolimus is not dialyzable to any significant extent. In mice and rats, the acute oral LD50 was greater than 800 mg/kg.
CONTRAINDICATIONS
Rapamune (sirolimus) is contraindicated in patients with a hypersensitivity to Rapamune [see WARNINGS AND PRECAUTIONS].
Last reviewed on RxList: 1/10/2011
This monograph has been modified to include the generic and brand name in many instances.
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