"The U.S. Food and Drug Administration today approved Liposorber LA-15 System to treat pediatric patients with primary focal segmental glomerulosclerosis (FSGS) either before transplant, or after renal (kidney) transplantation in which there is re"...
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Details with Side Effects
Reports of overdose with Rapamune have been received; however, experience has been limited. In general, the adverse effects of overdose are consistent with those listed in the adverse reactions section [see ADVERSE REACTIONS].
General supportive measures should be followed in all cases of overdose. Based on the low aqueous solubility and high erythrocyte and plasma protein binding of sirolimus, it is anticipated that sirolimus is not dialyzable to any significant extent. In mice and rats, the acute oral LD50 was greater than 800 mg/kg.
Rapamune is contraindicated in patients with a hypersensitivity to Rapamune [see WARNINGS AND PRECAUTIONS].
Last reviewed on RxList: 1/14/2013
This monograph has been modified to include the generic and brand name in many instances.
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