Rapamune (Sirolimus) Patient Information: Missed a Dose and What Should I Avoid at RxList

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May 27, 2012

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Kidney Failure »

What are the kidneys?

The kidneys play key roles in body function, not only by filtering the blood and getting rid of waste products, but also by balancing levels of electrolyte levels in the body, controlling blood pressure, and stimulating the production of red blood cells.

The kidneys are located in the abdomen toward the back, normally one on each side of the spine. They get their blood supply through the renal arteries directly from the aorta and send blood back to the heart via the renal veins to the vena cava. (The term "renal" is derived from the Latin name for kidney.)

The kidneys have the ability to monitor the amount of body fluid, the concentrations of electrolytes like sodium and potassium, and the acid-base balance of the body. They filter waste products of body metabolism, like urea from protein metabolism and uric acid from DNA breakdown. Two waste products in the blood can be measured: blood urea nitrogen (BUN) ...

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Rapamune Patient Information including If I Miss a Dose

What happens if I miss a dose (Rapamune)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Rapamune)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a sirolimus overdose are not known but may include some of the side effects listed in this medication guide.

What should I avoid while taking sirolimus (Rapamune)?

Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Do not mix this medicine with grapefruit juice. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.

Do not receive a vaccine while you are being treated with sirolimus. The vaccine may not work as well during this time, and may not fully protect you from disease.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Sirolimus may increase your risk of skin cancer. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

What other drugs will affect sirolimus (Rapamune)?

Tell your doctor if you are using any of the following drugs:

amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet);
bromocriptine (Parlodel);
cimetidine (Tagamet);
cisapride (Propulsid);
danazol (Danocrine);
metoclopramide (Reglan );
rifampin (Rifater, Rifadin, Rimactane), rifabutin (Mycobutin), rifapentine (Priftin);
St. John's wort;
tacrolimus (Prograf);
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);
an antibiotic such clarithromycin (Biaxin), erythromycin (E-Mycin, Ery-Tab, Erythrocin, E.E.S), telithromycin (Ketek), capreomycin (Capastat), or troleandomycin (Tao);
an antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
a calcium channel blocker such as diltiazem (Tiazac, Cardizem), nicardipine (Cardene), or verapamil (Calan, Covera, Verelan);
HIV medicines such as indinavir (Crixivan) or ritonavir (Norvir); or
seizure medicine such as carbamazepine (Tegretol), phenytoin (Dilantin), phenobarbital (Luminal).

This list is not complete and there may be other drugs that can interact with sirolimus. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sirolimus.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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