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Rapamune

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Rapamune

Rapamune Patient Information Including Side Effects

Brand Names: Rapamune

Generic Name: sirolimus (Pronunciation: sih RO lim us)

What is sirolimus (Rapamune)?

Sirolimus lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine (Neoral, Sandimmune) and a steroid medicine such as prednisone.

Sirolimus may also be used for purposes not listed in this medication guide.

Rapamune 1 mg

triangular, white, imprinted with RAPAMUNE 1 mg

Rapamune 2 mg

triangular, beige, imprinted with RAPAMUNE 2 mg

What are the possible side effects of sirolimus (Rapamune)?

Sirolimus may cause a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast heart rate;
  • pain when you breathe, feeling short of breath;
  • chest pain, feeling weak or tired;
  • coughing up blood or mucus;
  • feeling like you might pass out;
  • pale skin, easy bruising or bleeding, weakness;
  • fever, chills, body aches, flu symptoms;
  • night sweats, weight loss;
  • swelling in your face, stomach, hands or feet;
  • rapid weight gain;
  • pain or burning when you urinate; or
  • slow healing of a wound.

Less serious side effects may include:

  • joint pain;
  • nausea, vomiting, diarrhea, constipation, stomach pain;
  • headache; or
  • acne or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Rapamune (sirolimus) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about sirolimus (Rapamune)?

Sirolimus may cause a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have any change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends.

The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use any other liquids to mix this medicine. Do not mix this medicine with grapefruit juice or potentially dangerous effects may result. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus.

If you also take cyclosporine, take the sirolimus at least 4 hours after taking cyclosporine.

Sirolimus can lower the blood cells that help your body fight infections. Avoid contact with people who have colds, the flu, or other contagious illnesses. Do not receive any vaccines without your doctor's advice. Contact your doctor immediately if you develop signs of infection.

Avoid getting this medication on your skin, or around your nose and mouth. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water.

Sirolimus may increase your risk of developing lymphoma or other forms of cancer. Talk with your doctor about your specific cancer risk.

Side Effects Centers
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Rapamune - User Reviews

Rapamune User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Rapamune sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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