May 28, 2017
Recommended Topic Related To:

Rattlesnake Antivenin

"Dec. 26, 2012 -- More than 4,000 preventable mistakes occur in surgery every year at a cost of more than $1.3 billion in medical malpractice payouts, according a new study.

How preventable? Well, researchers call them "never events" because"...


Rattlesnake Antivenin

Rattlesnake Antivenin (antivenin crotalidae polyvalent)
(Crotalidae Polyvalent [Equine])


Pit viper bites may cause severe tissue damage or fatal envenomation, or both. The physician responsible for treatment of an envenomated patient should be familiar with the contents of this brochure and the pertinent medical literature concerning current concepts of first-aid and general supportive therapy as presented in the references listed at the end of this pamphlet.



Antivenin (Crotalidae) Polyvalent, Wyeth, is a refined and concentrated preparation of serum globulins obtained by fractionating blood from healthy horses immunized with the following venoms: Crotalus adamanteus (Eastern diamond rattlesnake), C. atrox (Western diamond rattlesnake), C. durissus terrificus (tropical rattlesnake, Cascabel), and Bothrops atrox ("Fer-de-lance''). Phenol, 0.25%, and thimerosal, 0.005%, are added as preservatives. The product is standardized by its ability to neutralize the lethal action of standard venoms by intravenous injection in mice.1 Dried from the frozen state, the lyophilized serum has a moisture content of less than 1% and is soluble on addition of the diluent contained in each package (Sterile Water for Injection, USP).

Antivenin (Crotalidae) Polyvalent, Wyeth (hereinafter referred to as Antivenin) contains protective substances capable of neutralizing the toxic effects of venoms of crotalids (pit vipers) native to North, Central, and South America, including rattlesnakes (Crotalus, Sistrurus); copperhead and cottonmouth moccasins (Agkistrodon), including A. halys of Korea and Japan; the Fer-de-lance and other species of Bothrops; the tropical rattler (Crotalus durissus and similar species); the Cantil (A. bilineatus); and bushmaster (Lachesis mutus) of South and Central America.

1. GINGRICH, W. & HOHENADEL, J.: Standardization of polyvalent antivenin. "Venoms", edited by E. Buckley and N. Porges. Publication No. 44, Amer. Assoc. for the Advancement of Science, Washington, D.C., 1956, Pages 337-80.

Last reviewed on RxList: 10/2/2008
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

Find out what women really need.

Related Drugs
Health Resources
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations