"The U.S. Food and Drug Administration today approved Dotarem (gadoterate meglumine) for use in magnetic resonance imaging (MRI) of the brain, spine and associated tissues of patients ages 2 years and older.
Dotarem is a gadolinium-based"...
(Generic versions may still be available.)
Patients should be advised:
- that grepafloxacin may be taken with or without meals.
- that grepafloxacin increases the effects of theophylline, and to advise their physician immediately if they are taking theophylline.
- that multivitamins (containing iron or zinc), antacids, (containing magnesium, calcium, or aluminum), sucralfate, or VIDEX (didanosine) chewable/buffered tablets or the pediatric powder for oral solution should not be taken within 4 hours before or 4 hours after taking grepafloxacin (see DRUG INTERACTIONS ).
- that grepafloxacin may increase the effects of other drugs metabolized by the liver, and to advise their physician of any of the drugs they are taking.
- to drink fluids liberally.
- that grepafloxacin may increase the effects of caffeine.
- that grepafloxacin may be associated with hypersensitivity reactions, even following a single dose, and to discontinue the drug at the first sign of skin rash, hives, or other skin reactions, a rapid heartbeat, difficulty in swallowing or breathing, or any other symptom of an allergic reaction (see WARNINGS ).
- that grepafloxacin may cause dizziness and lightheadedness; therefore, patients should know how they react to this drug before they operate an automobile or machinery or engage in activities requiring mental alertness and coordination.
- to discontinue treatment; rest and refrain from exercise; and to contact their physician immediately if they experience pain, inflammation or rupture of a tendon .
- to avoid excessive sunlight or artificial ultraviolet light while taking grepafloxacin and to discontinue therapy if phototoxicity (e.g., sunburn-like reaction or skin eruptions) occurs.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Raxar Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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