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Recombinate

Last reviewed on RxList: 12/29/2016
Recombinate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/8/2016

Recombinate Antihemophilic Factor (Recombinant) is a naturally occurring protein in the blood that helps blood to clot used to treat or prevent bleeding episodes in adults and children with hemophilia A. Recombinate Antihemophilic Factor is also used to control bleeding related to surgery or dentistry in a person with hemophilia, and to prevent joint damage in people age 16 or older with severe hemophilia A and no prior joint damage. Recombinate Antihemophilic Factor is not for use in people with von Willebrand disease. Common side effects of Recombinate Antihemophilic Factor include:

  • flushing of the face (warmth, redness, itching, or tingling feeling under your skin)
  • headache
  • nausea
  • vomiting, and
  • fast heartbeat and can be lessened by giving this medication more slowly

Other side effects of Recombinate Antihemophilic Factor include:

  • injection site reactions (burning, redness, irritation, swelling, or stinging)
  • fever
  • chills
  • sore throat
  • cough
  • runny nose
  • unusual or unpleasant taste in your mouth
  • skin itching or rash
  • joint pain or swelling, or
  • dizziness

Physician supervision of the dosage of Recombinate is required. Recombinate may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Recombinate should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Recombinate Antihemophilic Factor (Recombinant) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Recombinate Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; feeling light-headed, fainting; swelling of your face, lips, tongue, or throat.

Stop using recombinant antihemophilic factor and call your doctor at once if you have a serious side effect such as:

  • chest pain;
  • easy bruising, increased bleeding episodes; or
  • bleeding from a wound or where the medicine was injected.

Less serious side effects may include:

  • sore throat, cough, runny nose;
  • fever or chills;
  • mild nausea, vomiting;
  • unusual or unpleasant taste in your mouth;
  • skin itching or rash;
  • warmth, redness, itching, or tingling under your skin;
  • joint pain or swelling;
  • dizziness;
  • headache; or
  • swelling, stinging, or irritation where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Recombinate (Antihemophilic Factor (Recombinant))

Recombinate Professional Information

SIDE EFFECTS

During the clinical studies conducted in the previously treated patient group, there were 13 infusion related minor adverse reactions reported out of 10,446 infusions (0.12%).

One patient experienced flushing and nausea during his first infusion which abated on decreasing the infusion rate. A second patient experienced mild fatigue during and following one infusion and a third patient had a series of eleven nose bleeds with a periodicity associated with the infusions.

The protein in greatest concentration in RECOMBINATE (antihemophilic factor (recombinant)) rAHF is Albumin (Human). Reactions associated with intravenous administration of albumin are extremely rare, although nausea, fever, chills or urticaria have been reported. Other allergic reactions could theoretically be encountered in the use of this Antihemophilic Factor preparation. See Information for Patients.

Read the entire FDA prescribing information for Recombinate (Antihemophilic Factor (Recombinant))

Related Resources for Recombinate

© Recombinate Patient Information is supplied by Cerner Multum, Inc. and Recombinate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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