July 26, 2016
Recommended Topic Related To:


"Jan. 29, 2013 -- Older women with heart problems may be at greater risk for mental changes that are thought to signal the beginnings of a type of dementia, a new study shows.

Called vascular dementia, it is a type of mental decline that"...



Refludan Patient Information including How Should I Take

What should I discuss with my health care provider before taking lepirudin (Refludan)?

Do not use this medication if you are allergic to lepirudin, or to a similar medication called bivalirudin (Angiomax).

Before using lepirudin, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney disease (or if you are on dialysis);
  • liver disease;
  • heart disease or infection;
  • untreated or uncontrolled high blood pressure;
  • a bleeding or blood clotting disorder (such as hemophilia);
  • any major bleeding from a surgery, injury, or other medical trauma;
  • a stomach ulcer or bleeding, intestinal bleeding;
  • a history of stroke; or
  • if you have recently had any type of biopsy.

If you have any of these conditions, you may not be able to use lepirudin, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment with lepirudin and aspirin.

It is not known whether lepirudin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take lepirudin (Refludan)?

Lepirudin is given as an injection through a needle placed into a vein. You will most likely receive this injection in a clinic or hospital setting.

Lepirudin must be given slowly through an IV infusion. This medication is usually given continuously for 2 to 10 days, or longer if needed.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis while you are receiving lepirudin.

Because lepirudin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Heart Health

Get the latest treatment options.

Atrial Fibrillation Quiz