"Nov. 2, 2012 -- Safety steps taken in the wake of the fungal meningitis outbreak have worsened drug shortages, raising questions about whether the U.S. must choose between the safety and the availability of crucial medicines.
During clinical trials of RELISTOR administered subcutaneously, no cases of methylnaltrexone bromide overdose were reported. In a study of healthy volunteers (n = 41), a single dose of 0.50 mg/kg administered as a subcutaneous injection was well-tolerated. A study of healthy volunteers noted orthostatic hypotension associated with a dose of 0.64 mg/kg administered as an IV bolus.
Management of Overdosage
No specific information is available on the treatment of overdose with RELISTOR (methylnaltrexone bromide) . In the event of overdose, employ the usual supportive measures, e.g., clinical monitoring and supportive therapy as dictated by the patient's clinical status. Signs or symptoms of orthostatic hypotension should be monitored, and treatment should be initiated, as appropriate.
RELISTOR (methylnaltrexone bromide) is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction.
Last reviewed on RxList: 8/13/2010
This monograph has been modified to include the generic and brand name in many instances.
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