Remodulin (Treprostinil Sodium) Drug Information: Overdosage and Contraindications

Pill Identifier Search

May 27, 2012

Remodulin

High Blood Pressure »

High blood pressure facts

High blood pressure (hypertension) is designated as either essential (primary) hypertension or secondary hypertension and is defined as a consistently elevated blood pressure exceeding 140/90 mm Hg.
High blood pressure is called "the silent killer" because it often causes no symptoms for many years, even decades, until it finally damages certain critical organs.
Poorly controlled high blood pressure ultimately can cause damage to blood vessels in the eye, thickening of the heart muscle and heart attacks, hardening of the arteries (arteriosclerosis), kidney failure, and strokes.
Most antihypertensive medications can be used alone or in combination. Some are used only in combination. Some are preferred over others in certain specific medical situations. And some are not to be used (contraindicated) in other situations.
Several classes of antihypertensive medications are available, including ACE i...

Read the High Blood Pressure article »

« Previous
1
2
3
4
5
6
7
8
9
10
11
12
13
Next »

Remodulin User Reviews >>

Remodulin

High Blood Pressure (Hypertension) Slideshow

Take the Salt Quiz!

Lowering Blood Pressure Exercise Tips Pictures

font size

OVERDOSE

Signs and symptoms of overdose with Remodulin (treprostinil sodium) during clinical trials are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of Remodulin (treprostinil sodium) .

In controlled clinical trials, seven patients received some level of overdose and in open-label follow-on treatment seven additional patients received an overdose; these occurrences resulted from accidental bolus administration of Remodulin (treprostinil sodium) , errors in pump programmed rate of administration, and prescription of an incorrect dose. In only two cases did excess delivery of Remodulin (treprostinil sodium) produce an event of substantial hemodynamic concern (hypotension, near-syncope).

One pediatric patient was accidentally administered 7.5 mg of Remodulin (treprostinil sodium) via a central venous catheter. Symptoms included flushing, headache, nausea, vomiting, hypotension and seizure-like activity with loss of consciousness lasting several minutes. The patient subsequently recovered.