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Side Effects


Gastrointestinal System Reactions

  1. anorexia
  2. gastric irritation
  3. nausea
  4. vomiting
  5. cramping
  6. diarrhea
  7. constipation
  8. jaundice (intrahepatic cholestatic jaundice)
  9. pancreatitis

Central Nervous System Reactions

  1. dizziness
  2. vertigo
  3. paresthesias
  4. headache
  5. xanthopsia

Hematologic Reactions

  1. leukopenia
  2. agranulocytosis
  3. thrombocytopenia
  4. aplastic anemia

Dermatologic —Hypersensitivity Reactions

  1. purpura
  2. photosensitivity
  3. rash
  4. urticaria
  5. necrotizing angiitis (vasculitis) (cutaneous vasculitis)

Cardiovascular Reaction

Orthostatic hypotension may occur and may be aggravated by alcohol, barbiturates or narcotics.


  1. hyperglycemia
  2. glycosuria
  3. hyperuricemia
  4. muscle spasm
  5. weakness
  6. restlessness

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.

Read the Renese (polythiazide) Side Effects Center for a complete guide to possible side effects


No information provided.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/24/2009

Side Effects

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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