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Renese Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/16/2016

Renese (polythiazide) is a diuretic used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, corticosteroid and estrogen therapy, and edema due to various forms of renal dysfunction, as well as management of hypertension used either alone or with other antihypertensive drugs. The brand name Renese is discontinued, but generic versions may be available. Common side effects of Renese (polythiazide) include:

  • low blood potassium or sodium levels
  • imbalance of blood potassium or sodium levels
  • weight loss
  • nausea
  • vomiting
  • cramping
  • diarrhea
  • constipation
  • yellowing of skin or eyes (jaundice)
  • dizziness
  • vertigo
  • numbness and tingling
  • headache
  • sensitivity to light
  • rash
  • hives
  • dizziness upon standing
  • high blood sugar
  • muscle spasm
  • weakness, or
  • restlessness

The usual dosage of Renese for diuretic therapy is 1 to 4 mg daily, and for antihypertensive therapy is 2 to 4 mg daily. Renese may interact with other drugs. Tell your doctor all medications and supplements you use. Renese is generally not recommended for use during pregnancy. It may harm a fetus. Tell your doctor if you are pregnant or become pregnant while taking Renese. This drug passes into breast milk. Breastfeeding while using Renese is not recommended.

Our Renese (polythiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Renese FDA Prescribing Information: Side Effects
(Adverse Reactions)


Gastrointestinal System Reactions

  1. anorexia
  2. gastric irritation
  3. nausea
  4. vomiting
  5. cramping
  6. diarrhea
  7. constipation
  8. jaundice (intrahepatic cholestatic jaundice)
  9. pancreatitis

Central Nervous System Reactions

  1. dizziness
  2. vertigo
  3. paresthesias
  4. headache
  5. xanthopsia

Hematologic Reactions

  1. leukopenia
  2. agranulocytosis
  3. thrombocytopenia
  4. aplastic anemia

Dermatologic -Hypersensitivity Reactions

  1. purpura
  2. photosensitivity
  3. rash
  4. urticaria
  5. necrotizing angiitis (vasculitis) (cutaneous vasculitis)

Cardiovascular Reaction

Orthostatic hypotension may occur and may be aggravated by alcohol, barbiturates or narcotics.


  1. hyperglycemia
  2. glycosuria
  3. hyperuricemia
  4. muscle spasm
  5. weakness
  6. restlessness

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.

Read the entire FDA prescribing information for Renese (Polythiazide)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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