Renova (Tretinoin Emollient Cream 0.05%) Drug Information: Side Effects and Drug Interactions

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May 27, 2012

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Wrinkles facts

Skin ages all over the body but much more so where there has been sun exposure. Changes brought on by sun damage (photoaging) include "dryness" (really roughness), sagginess, skin growths like keratoses ("liver spots"), and wrinkles.
Wrinkles in turn can be divided into two categories: fine surface lines and deep furrows. Wrinkle treatments are in general much more effective for fine lines. Deeper creases may require more aggressive techniques, such as plastic surgery.
Factors that promote wrinkling include smoking, skin type (people with light-colored skin and blue eyes are more susceptible to sun damage), heredity (some families wrinkle more), hairstyle (depending on how much skin is covered by hair and protected from the sun), dress (again, by determining which skin is exposed), and occupational and recreational sun exposure over the course of many years.

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SIDE EFFECTS

(See WARNINGS and PRECAUTIONS sections.)

In double-blind, vehicle-controlled studies involving 179 patients who applied RENOVA (tretinoin emollient cream 0.05%) 0.05% to their face, adverse reactions associated with the use of RENOVA (tretinoin emollient cream 0.05%) 0.05% were limited primarily to the skin. During these trials, 4% of patients had to discontinue use of RENOVA (tretinoin emollient cream 0.05%) 0.05% because of adverse reactions. These discontinuations were due to skin irritation or related cutaneous adverse reactions.

Local reactions such as peeling, dry skin, burning, stinging, erythema, and pruritus were reported by almost all subjects during therapy with RENOVA (tretinoin emollient cream 0.05%) 0.05%. These signs and symptoms were usually of mild to moderate severity and generally occurred early in therapy. In most patients the dryness, peeling, and redness recurred after an initial (24 week) decline.

In spontaneous post-marketing adverse event reporting for RENOVA (tretinoin emollient cream 0.05%) 0.05%, approximately 2% of those were for skin hypo- or hyperpigmentation. Other spontaneously reported adverse events predominantly appear to be local reactions similar to those seen in clinical trials.

DRUG INTERACTIONS

Concomitant topical medications, medicated or abrasive soaps, shampoos, cleansers, cosmetics with a strong drying effect, products with high concentrations of alcohol, astringents, spices or lime, permanent wave solutions, electrolysis, hair depilatories or waxes, and products that may irritate the skin should be used with caution in patients being treated with RENOVA (tretinoin emollient cream 0.05%) because they may increase irritation with RENOVA (tretinoin emollient cream 0.05%) .

RENOVA (tretinoin emollient cream 0.05%) should not be administered if the patient is also taking drugs known to be photosensitizers (e.g., thiazides, tetracyclines, fluoroquinolones, phenothiazines, sulfonamides) because of the possibility of augmented phototoxicity.

Last reviewed on RxList: 12/10/2008
This monograph has been modified to include the generic and brand name in many instances.