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Inform patients to take Renvela as directed with meals and adhere to their prescribed diets.

For patients using an oral medication where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy, advise the patient to take the oral medication at least one hour before or three hours after Renvela. Blood levels of the oral medication should be monitored, if applicable, to determine if there is a significant interaction between the oral medication and Renvela.

For Renvela powder, brief the patient on preparation of the powder in water.

Sevelamer Carbonate Powder Preparation Instructions

The entire contents of each 0.8 or 2.4 g packet should be placed in a cup and mixed thoroughly with the amount of water described in Table 7.

Table 7: Sevelamer Carbonate Powder Preparation Instructions

Renvela Powder Packet Strength Minimum amount of water for dose preparation (either ounces, mL or teaspoon/Tablespoon)
ounces mL tsp/Tbsp
0.8 g 1 30 6 teaspoons/2 Tablespoons
2.4 g 2 60 4 Tablespoons

Multiple packets may be mixed together with the appropriate amount of water. Patients should be instructed that the powder does not dissolve and therefore it should be stirred vigorously just before drinking. The entire preparation should be consumed within 30 minutes.

Adverse Reactions

Renvela may cause constipation that if left untreated, may lead to severe complications. Patients should be cautioned to report new onset or worsening of existing constipation promptly to their physician.

Last reviewed on RxList: 3/22/2016
This monograph has been modified to include the generic and brand name in many instances.

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