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home > drugs a-z list > rescriptor (delavirdine mesylate) drug center > rescriptor (delavirdine mesylate) drug - overdosage and contraindications
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Rescriptor
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Rescriptor
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OVERDOSE
Human experience of acute overdose with RESCRIPTOR (delavirdine mesylate) is limited.
Management of Overdosage
Treatment of overdosage with RESCRIPTOR (delavirdine mesylate) should consist of general supportive measures, including monitoring of vital signs and observation of the patient's clinical status. There is no specific antidote for overdosage with RESCRIPTOR (delavirdine mesylate) . If indicated, elimination of unabsorbed drug should be achieved by emesis or gastric lavage. Since delavirdine is extensively metabolized by the liver and is highly protein-bound, dialysis is unlikely to result in significant removal of the drug.
CONTRAINDICATIONS
RESCRIPTOR (delavirdine mesylate) Tablets are contraindicated in patients with known hypersensitivity to any of its ingredients. Coadministration of RESCRIPTOR (delavirdine mesylate) is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events. These drugs are listed in Table 5. Also, see PRECAUTIONS, Table 6, Drugs That Should Not Be Coadministered With RESCRIPTOR (delavirdine mesylate) .
Table 5. Drugs That Are Contraindicated With RESCRIPTOR (delavirdine mesylate)
| Drug Class | Drugs Within Class That Are Contraindicated With RESCRIPTOR |
| Antihistamines | Astemizole, terfenadine |
| Ergot derivatives | Dihydroergotamine, ergonovine, ergotamine, methylergonovine |
| GI motility agent | Cisapride |
| Neuroleptic | Pimozide |
| Sedative/hypnotics | Alprazolam, midazolam, triazolam |
Last reviewed on RxList: 11/25/2008
This monograph has been modified to include the generic and brand name in many instances.
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