Rescula (Unoprostone isopropyl) Drug Information: Overdosage and Contraindications

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May 27, 2012

Rescula

Glaucoma »

What is glaucoma?

Glaucoma is a disease of the major nerve of vision, called the optic nerve. The optic nerve receives light-generated nerve impulses from the retina and transmits these to the brain, where we recognize those electrical signals as vision. Glaucoma is characterized by a particular pattern of progressive damage to the optic nerve that generally begins with a subtle loss of side vision (peripheral vision). If glaucoma is not diagnosed and treated, it can progress to loss of central vision and blindness.

Glaucoma is usually, but not always, associated with elevated pressure in the eye (intraocular pressure). Generally, it is this elevated eye pressure that leads to damage of the eye (optic) nerve. In some cases, glaucoma may occur in the presence of normal eye pressure. This form of glaucoma is believed to be caused by poor regulation of blood flow to the optic nerve.

How common is glaucoma?

Worldwide, glaucoma...

Read the Glaucoma article »

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Rescula

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

OVERDOSE

There is no published information available regarding overdosage with RESCULA (unoprostone isopropyl) 0.15%. The risk of adverse effects due to accidental oral ingestion is very low since the amount of active ingredient in each bottle is limited (7.5 mg in a 5 mL vial). Accidental ingestion of a vial by a child with 30 kg body weight will amount to 0.25 mg/kg body weight.

If overdosage does occur, treatment should be symptomatic.

ANIMAL TOXICOLOGY

In cynomolgus monkeys administered Rescula (unoprostone isopropyl) for twelve months at 150 mg/eye/day (equal to the human dose), one of ten animals exhibited increased pigmentation of the iris. The incidence did not change when the administered dose was increased to 300 mg/eye/day (twice the human dose) for an additional six months.