Retisert (Fluocinolone Acetonide Intravitreal Implant) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Retisert

Uveitis »

Introduction

Uveitis (pronounced you-vee-EYE-tis) is basically an inflammation of the eye. The condition involves all inflammatory processes of the middle layers of the eye, also called the uveal tract or uvea. The uvea includes the iris (colored part of the eye), choroid (a thin membrane containing many blood vessels) and ciliary body (the part of the eye that joins these together).

The uvea is very important because its many veins and arteries transport blood to the parts of the eye that are critical for vision.

Learn more about the structures that make up the eye in the article titled " The Amazing Human Eye ."

What Are the Symptoms of Uveitis?

Symptoms of uveitis may include:

Eye redness and irritation
Blurred vision
Eye pain
Increased sensitivity to light ...

Read the Uveitis article »

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Retisert

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RETISERT®
(fluocinolone acetonide) Intravitreal Implant

DRUG DESCRIPTION

RETISERT® (fluocinolone acetonide intravitreal implant) 0.59 mg is a sterile implant designed to release fluocinolone acetonide locally to the posterior segment of the eye at a nominal initial rate of 0.6 μg/day, decreasing over the first month to a steady state between 0.3-0.4 μg/day over approximately 30 months. The drug substance is the synthetic corticosteroid fluocinolone acetonide, represented by the following structural formula:

RETISERT (fluocinolone acetonide intravitreal implant) Structural Formula Illustration

C₂₄H₃₀F₂O₆ Mol. Wt. 452.50

Chemical Name: Pregna-1,4-diene-3,20-dione,6,9-difluoro-11,21-dihydroxy- 16,17-[(1-methyl-ethylidene)bis(oxy)],(6α,11β ,16α)-.

Fluocinolone acetonide is a white crystalline powder, insoluble in water, and soluble in methanol. It has a melting point of 265-266°C.

Each RETISERT consists of a tablet containing 0.59 mg of the active ingredient, Fluocinolone Acetonide, USP, and the following inactives: microcrystalline cellulose, polyvinyl alcohol, and magnesium stearate.

What are the possible side effects of fluocinolone ophthalmic implant (Retisert)?

For the first 1 to 4 weeks after receiving the implant, you may have a temporary decrease in vision. Call your doctor if your vision does not return to normal after 4 weeks. Fluocinolone ophthalmic implant will not correct vision problems (such as near-sightedness or far-sightedness) that you had before receiving the implant.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you...

Read All Potential Side Effects and See Pictures of Retisert »

Last reviewed on RxList: 8/2/2011
This monograph has been modified to include the generic and brand name in many instances.