Retisert (Fluocinolone Acetonide Intravitreal Implant) Drug Overview and Uses for Patients and Caregivers at RxList

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May 27, 2012

Retisert

Uveitis »

Introduction

Uveitis (pronounced you-vee-EYE-tis) is basically an inflammation of the eye. The condition involves all inflammatory processes of the middle layers of the eye, also called the uveal tract or uvea. The uvea includes the iris (colored part of the eye), choroid (a thin membrane containing many blood vessels) and ciliary body (the part of the eye that joins these together).

The uvea is very important because its many veins and arteries transport blood to the parts of the eye that are critical for vision.

Learn more about the structures that make up the eye in the article titled " The Amazing Human Eye ."

What Are the Symptoms of Uveitis?

Symptoms of uveitis may include:

Eye redness and irritation
Blurred vision
Eye pain
Increased sensitivity to light ...

Read the Uveitis article »

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Retisert

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RETISERT®
(fluocinolone acetonide) Intravitreal Implant

DRUG DESCRIPTION

RETISERT® (fluocinolone acetonide intravitreal implant) 0.59 mg is a sterile implant designed to release fluocinolone acetonide locally to the posterior segment of the eye at a nominal initial rate of 0.6 μg/day, decreasing over the first month to a steady state between 0.3-0.4 μg/day over approximately 30 months. The drug substance is the synthetic corticosteroid fluocinolone acetonide, represented by the following structural formula:

RETISERT (fluocinolone acetonide intravitreal implant) Structural Formula Illustration

C₂₄H₃₀F₂O₆ Mol. Wt. 452.50

Chemical Name: Pregna-1,4-diene-3,20-dione,6,9-difluoro-11,21-dihydroxy- 16,17-[(1-methyl-ethylidene)bis(oxy)],(6α,11β ,16α)-.

Fluocinolone acetonide is a white crystalline powder, insoluble in water, and soluble in methanol. It has a melting point of 265-266°C.

Each RETISERT consists of a tablet containing 0.59 mg of the active ingredient, Fluocinolone Acetonide, USP, and the following inactives: microcrystalline cellulose, polyvinyl alcohol, and magnesium stearate.

Last reviewed on RxList: 8/2/2011
This monograph has been modified to include the generic and brand name in many instances.