Revatio (Sildenafil Citrate) Drug Overview of Drug Interactions and Missed Dose for Patients and Caregivers at RxList

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May 27, 2012

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Pulmonary Hypertension »

What are pulmonary arteries?

The human body has two major sets of blood vessels that distribute blood from the heart to the body. One set pumps blood from the right heart to the lungs and the other from the left heart to the rest of the body.

The portion of the circulation that distributes oxygen-rich blood from the left side of the heart, throughout the body, is referred to as the systemic circulation.
The blood then returns from the body to the right side of the heart and passes through the lungs to replenish oxygen.
It then returns to the left side of the heart for another round through the systemic circulation.
The portion of the circulation that distributes the blood from the right side of the heart to the lungs is referred to as the pulmonary (lung) circulation.
The pulmonary arteries are the major blood vessels that carry blood from the rig...

Read the Pulmonary Hypertension article »

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DRUG INTERACTIONS: See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: certain recreational drugs ("poppers") containing amyl/butyl nitrite, alpha blocker medication (such as doxazosin, prazosin, terazosin), bosentan.

Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Examples include cimetidine, anticonvulsants (such as carbamazepine, phenobarbital, phenytoin), azole antifungals (such as ketoconazole, itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), HIV drugs (such as ritonavir, saquinavir, delavirdine), St. John's wort, among others.

Sildenafil may interact with certain chest pain medications (nitrates such as nitroglycerin, isosorbide) causing a dangerous drop in blood pressure. Do not take sildenafil if you also use nitrates. Talk with your doctor or pharmacist for more details and for information on what to do if you get unusual chest pain.

Do not take this medication with any other product that contains sildenafil or other similar medications for erection problems/pulmonary hypertension (such as tadalafil, vardenafil).

OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include severe dizziness, fainting, painful/prolonged erection.

NOTES: Do not share this medication with others.

Medical tests (such as blood pressure, eye exams) may be performed periodically to monitor your progress or check for side effects.

MISSED DOSE: Not applicable.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.