Revex (Nalmefene Hydrochloride) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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Revex

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Revex
(nalmefene hydrochloride) Injection

DRUG DESCRIPTION

REVEX (nalmefene hydrochloride injection), an opioid antagonist, is a 6-methylene analogue of naltrexone. The chemical structure is shown below:

Molecular Formula: C₂₁H₂₅NO₃Â· HCl

Molecular Weight: 375.9, CAS # 58895-64-0

Chemical Name: 17-(Cyclopropylmethyl)-4,5 -epoxy-6-methylenemorphinan-3,14-diol, hydrochloride salt.

Nalmefene hydrochloride is a white to off-white crystalline powder which is freely soluble in water up to 130 mg/mL and slightly soluble in chloroform up to 0.13 mg/mL, with a pKa of 7.6.

REVEX (nalmefene hydrochloride) is available as a sterile solution for intravenous, intramuscular, and subcutaneous administration in two concentrations, containing 100 mg or 1.0 mg of nalmefene free base per mL. The 100 mg/mL concentration contains 110.8 mg of nalmefene hydrochloride and the 1.0 mg/mL concentration contains 1.108 mg of nalmefene hydrochloride per mL. Both concentrations contain 9.0 mg of sodium chloride per mL and the pH is adjusted to 3.9 with hydrochloric acid.

Concentrations and dosages of REVEX (nalmefene hydrochloride) are expressed as the free base equivalent of nalmefene.

What are the possible side effects of nalmefene (Revex)?

If you are addicted to narcotics or have been using an opioid medicine for a long time, you may have unpleasant withdrawal symptoms when you receive nalmefene to reverse the effects of a narcotic overdose.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have any of these symptoms, some of which may be signs that you need to receive additional doses of nalmefene: