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Reyataz

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Entry inhibitors block HIV entry into CD4+ cells.

Fusion inhibitors
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Reyataz

PATIENT INFORMATION

REYATAZ®
(RAY-ah-taz)
(atazanavir) Capsules

REYATAZ®
(RAY-ah-taz)
(atazanavir) Oral Powder

Important: Ask your healthcare provider or pharmacist about medicines that should not be taken with REYATAZ. For more information, see “Who should not take REYATAZ?” and “What should I tell my healthcare provider before taking REYATAZ?”

Read this Patient Information before you start taking REYATAZ and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment.

What is REYATAZ?

REYATAZ is a prescription HIV-1 (Human Immunodeficiency Virus) medicine that is used with other antiretroviral medicines to treat HIV-1 infection in adults and children 3 months of age and older and who weigh at least 22 pounds (10 kg).

HIV is the virus that causes AIDS (Acquired Immunodeficiency Syndrome).

REYATAZ should not be used in children younger than 3 months of age.

When used with other antiretroviral medicines to treat HIV infection, REYATAZ may help:

  • reduce the amount of HIV in your blood. This is called viral load.
  • increase the number of CD4+ (T) cells in your blood that help fight off other infections.

Reducing the amount of HIV and increasing the CD4+ (T) cells in your blood may help improve your immune system. This may reduce your risk of death or getting infections that can happen when your immune system is weak (opportunistic infections).

REYATAZ does not cure HIV infection or AIDS. You must stay on continuous HIV therapy to control HIV infection and decrease HIV-related illnesses.

Avoid doing things that can spread HIV infection to others:

  • Do not share or re-use needles or other injection equipment.
  • Do not share personal items that can have blood or body fluids on them, like toothbrushes and razor blades.
  • Do not have any kind of sex without protection. Always practice safer sex by using a latex or polyurethane condom to lower the chance of sexual contact with any body fluids such as semen, vaginal secretions, or blood.

Ask your healthcare provider if you have any questions about how to prevent passing HIV to other people

Who should not take REYATAZ?

Do not take REYATAZ if you:

  • are allergic to atazanavir or any of the ingredients in REYATAZ. See the end of this leaflet for a complete list of ingredients in REYATAZ.
  • are taking any of the following medicines. Taking REYATAZ with these medicines may affect how REYATAZ works. REYATAZ may cause serious life-threatening side effects or death when used with these medicines:
  • alfuzosin (UROXATRAL®)
  • cisapride (PROPULSID®)
    • ergot medicines including:
    • ergotamine tartrate (CAFERGOT®, MIGERGOT®, ERGOMAR®, ERGOSTAT®, MEDIHALER®, Ergotamine, WIGRAINE®, WIGRETTES®)
    • dihydroergotamine mesylate (D.H.E. 45®, MIGRANAL®)
    • methylergonovine (METHERGINE®)
  • indinavir (CRIXIVAN®)
  • irinotecan (CAMPTOSAR®)
  • lovastatin (ADVICOR®, ALTOPREV® MEVACOR®)
  • midazolam (VERSED®), when taken by mouth for sedation
  • nevirapine (VIRAMUNE®, VIRAMUNE XR®)
  • pimozide (ORAP®)
  • rifampin (RIMACTANE®, RIFADIN®, RIFATER®, RIFAMATE®)
  • sildenafil (REVATIO®), when used for the treatment of pulmonary arterial hypertension
  • simvastatin (ZOCOR®, VYTORIN, SIMCOR)
  • St. John's wort (Hypericum perforatum)
  • triazolam (HALCION®)

Serious problems can happen if you or your child take any of the medicines listed above with REYATAZ.

What should I tell my healthcare provider before taking REYATAZ?

Before taking REYATAZ, tell your healthcare provider if you:

  • have heart problems
  • have liver problems, including hepatitis B or C virus infection
  • have phenylketonuria (PKU). REYATAZ oral powder contains phenylalanine as part of the artificial sweetener aspartame. The artificial sweetener can be harmful to people with PKU.
  • are receiving dialysis treatment
  • have diabetes
  • have hemophilia
  • have any other medical conditions
  • are pregnant or plan to become pregnant. It is not known if REYATAZ will harm your unborn baby. Pregnant women have developed a serious condition called lactic acidosis (a build-up of lactic acid in the blood) when taking REYATAZ with other HIV medicines called nucleoside analogues.
    • Hormonal forms of birth control, such as injections, vaginal rings or implants, contraceptive patch, and some birth control pills may not work during treatment with REYATAZ. Talk to your healthcare provider about forms of birth control that may be used during treatment with REYATAZ.
    • Pregnancy Registry. There is a pregnancy registry for women who take antiviral medicines during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry.
    • After your baby is born, tell your healthcare provider if your baby's skin or the white part of his/her eyes turns yellow.
  • are breastfeeding or plan to breastfeed. Do not breastfeed if you are taking REYATAZ. You should not breastfeed if you have HIV because of the risk of passing HIV to your baby. It is not known if REYATAZ passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REYATAZ may affect the way other medicines work, and other medicines may affect how REYATAZ works and may cause serious side effects. If you take certain medicines with REYATAZ, the amount of REYATAZ in your body may be too low and it may not work to help control your HIV infection. The HIV virus in your body may become resistant to REYATAZ or other HIV medicines that are like it. Especially tell your healthcare provider if you take any of the medicines below:

The following medicines should not be taken during your treatment with REYATAZ:

  • boceprevir (VICTRELIS®)
  • salmeterol (SEREVENT DISKUS®) and salmeterol with fluticasone (ADVAIR DISKUS®, ADVAIR HFA®)
  • voriconazole (VFEND®)

If you take any of the following medicines during treatment with REYATAZ, your healthcare provider may need to change the dose of the medicine or change the dose of REYATAZ, or your healthcare provider may need to monitor you more closely:

  • medicines used to treat abnormal heart rhythm:
    • amiodarone (CORDARONE®, NEXTERONE®, PACERONE®)
    • lidocaine
    • quinidine
  • allergy or asthma medicines (nasal spray or inhaled treatment):
    • fluticasone propionate (FLONASE®, FLOVENT DISKUS®, FLOVENT HFA®)
  • an antibiotic used to treat tuberculosis (TB):
    • rifabutin (MYCOBUTIN®)
  • the anticoagulant (blood thinner) medicine:
    • warfarin (COUMADIN®, JANTOVEN®)
  • antidepressant medicines:
    • amitriptyline
    • desipramine (NORPRAMIN®)
    • doxepin (SILENOR®)
    • trazodone (OLEPTRO®)
    • trimipramine (SURMONTIL®)
    • imipramine (TOFRANIL®, TOFRANIL-PM®)
    • protriptyline (VIVACTIL®)
  • the chest pain medicine:
    • bepridil (VASCOR®)
  • cholesterol-lowering medicines:
    • atorvastatin (LIPITOR®)
    • rosuvastatin (CRESTOR®)
  • erectile dysfunction medicines:
    • sildenafil (VIAGRA®)
    • tadalafil (CIALIS®)
    • vardenafil (LEVITRA®, STAXYN®)
  • a medicine for gout or treatment of familial Mediterranean fever:
  • organ transplant rejection medicines:
    • cyclosporine (SANDIMMUNE®, NEORAL®, GENGRAF®)
    • sirolimus (RAPAMUNE®)
    • tacrolimus (PROGRAF®, ASTAGRAF XL®)
  • pain and addiction medicines:
  • pulmonary arterial hypertension medicines:
    • bosentan (TRACLEER®)
    • tadalafil (ADCIRCA®)
  • medicine to treat fungal infections
    • ketoconazole (NIZORAL®)
    • itraconazole (SPORANOX®, ONMEL®)

People who take sildenafil (VIAGRA®), tadalafil (CIALIS®, ADCIRCA®) or vardenafil (LEVITRA®, STAXYN®) with REYATAZ may have a higher risk of certain side effects. Tell your healthcare provider right away if you take any of these medicines and have any of the following side effects:

  • lightheadedness, especially when standing
  • fainting
  • changes in your vision
  • an erection that lasts more than 4 hours

If you take any of the following medicines, your healthcare provider may change the dose or the time you take REYATAZ or the other medicine:

  • antiepileptic medicines:
    • carbamazepine (CARBATROL®, EPITOL®, TEGRETOL®, TEGRETOL-XR®, EQUETRO®, TERIL®)
    • phenytoin (DILANTIN®)
    • lamotrigine (LAMICTAL®, LAMICTAL CD®, LAMICTAL XR®, LAMICTAL ODT®)
  • calcium channel blockers such as:
    • diltiazem (CARDIZEM®, CARDIZEM CD®, CARDIZEM LA®, TIAZAC®, CARTIA XT®, DILACOR XR®, DILT-CD®, DILTZAC®, TAZTIA XT®)
    • verapamil (COVERA-HS®, CALAN®, CALAN SR®, VERALAN®, VERELAN PM®)
    • felodipine (PLENDIL®)
    • nifedipine (ADALAT CC®, AFEDITAB CR®, PROCARDIA®, PROCARDIA XL®)
    • nicardipine (CARDENE®, CARDENE SR®)
  • indigestion, heartburn, or ulcer medicines:
    • cimetidine (TAGAMET®)
    • esomeprazole (NEXIUM®)
    • famotidine (PEPCID®, PEPCID AC®)
    • rabeprazole (ACIPHEX®, ACIPHEX SPRINKLE™)
    • nizatidine (AXID®)
    • lansoprazole (PREVACID®)
    • omeprazole (PRILOSEC®)
    • pantoprazole (PROTONIX®)
    • ranitidine (ZANTAC®)
  • antacids or buffered medicines
  • antibiotics or antiviral medicines
    • clarithromycin (BIAXIN®, BIAXIN XL®)
    • didanosine (VIDEX®, VIDEX EC®)
    • efavirenz (SUSTIVA®)
    • rifabutin (MYCOBUTIN®)
    • ritonavir (NORVIR®)
    • saquinavir (INVIRASE®)
    • tenofovir disoproxil fumarate (VIREAD®)

Ask your healthcare provider or pharmacist if you are not sure if your medicine is one that is listed above.

Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

Your healthcare provider and your pharmacist can tell you if you can take these medicines with REYATAZ. Do not start any new medicines while you are taking REYATAZ without first talking with your healthcare provider or pharmacist. You can ask your healthcare provider or pharmacist for a list of medicines that can interact with REYATAZ.

How should I take REYATAZ?

  • Take REYATAZ exactly as your healthcare provider tells you to.
  • Do not change your dose or stop taking REYATAZ unless your healthcare provider tells you to.
  • Stay under the care of your healthcare provider during treatment with REYATAZ.
  • REYATAZ must be used with other antiretroviral medicines.
  • Take REYATAZ 1 time each day.
  • REYATAZ comes as capsules and oral powder.
  • Take REYATAZ capsules and oral powder with food.
  • Swallow the capsules whole. Do not open the capsules.
  • REYATAZ oral powder must be mixed with food or liquid. Your child's healthcare provider will prescribe the right dose of REYATAZ based on your child's weight.
  • REYATAZ oral powder must be taken with ritonavir.
  • If you miss a dose of REYATAZ, take it as soon as you remember. Then take the next dose at your regular time. Do not take 2 doses at the same time.
  • If you take too much REYATAZ,call your healthcare provider or go to the nearest hospital emergency room right away.

When your supply of REYATAZ starts to run low, get more from your healthcare provider or pharmacy. It is important not to run out of REYATAZ. The amount of HIV-1 in your blood may increase if the medicine is stopped for even a short time. The virus may become resistant to REYATAZ and harder to treat.

What are the possible side effects of REYATAZ?

REYATAZ can cause serious side effects, including:

  • A change in the way your heart beats (heart rhythm change). Tell your healthcare provider right away if you get dizzy or lightheaded. These could be symptoms of a heart problem.
  • Skin rash. Skin rash is common with REYATAZ but can sometimes be severe. Skin rash usually goes away within 2 weeks without any change in treatment. Severe rash may develop in association with other symptoms which could be serious. If you develop a severe rash or a rash with any of the following symptoms, stop taking REYATAZ and call your healthcare provider right away:
    • general feeling of discomfort or “flu-like” symptoms
    • fever
    • muscle or joint aches
    • red or inflamed eyes, like “pink eye” (conjunctivitis)
    • blisters
    • mouth sores
    • swelling of your face
    • painful, warm, or red lump under your skin
  • Yellowing of your skin or the white part of your eyes is common with REYATAZ but may be a symptom of a serious problem. These effects may be due to increases in bilirubin levels in your blood (bilirubin is made by the liver). Although these effects may not be damaging to your liver, skin, or eyes, tell your healthcare provider right away if your skin or the white part of your eyes turns yellow.
  • Liver problems. If you have liver problems, including hepatitis B or C infection, your liver problems may get worse when you take REYATAZ. Your healthcare provider will do blood tests to check your liver before you start REYATAZ and during treatment. Tell your healthcare provider right away if you get any of the following symptoms:
    • your skin or the white part of your eyes turn yellow
    • dark “tea-colored” urine
    • light colored stools
    • nausea
    • itching
    • stomach-area pain
  • Kidney stoneshave happened in some people who take REYATAZ. Tell your healthcare provider right away if you get symptoms of kidney stones which may include, pain in your low back or low stomach-area, blood in your urine, or pain when you urinate.
  • Gallbladder problems have happened in some people who take REYATAZ. Tell your healthcare provider right away if you get symptoms of gallbladder problems which may include:
    • pain in the right or middle upper stomach-area
    • fever
    • nausea and vomiting
    • your skin or the white part of your eyes turns yellow
  • Diabetes and high blood sugar (hyperglycemia) have happened or have worsened in some people who take protease inhibitor medicines like REYATAZ. Some people have had to start taking medicine to treat diabetes or have had to change their diabetes medicine.
  • Changes in your immune system (Immune Reconstitution Syndrome)can happen when you start taking HIV medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare provider if you start having new symptoms after starting your HIV medicine.
  • Changes in body fat can happen in people taking HIV medicine. These changes may include increased amount of fat in the upper back and neck (“buffalo hump”), breast, and around the main part of your body (trunk). Loss of fat from the legs, arms, and face may also happen. The cause and long-term health effects of these conditions are not known.
  • Increased bleeding problems in people with hemophilia have happened when taking protease inhibitors like REYATAZ.

The most common side effects of REYATAZ include:

  • nausea
  • dizziness
  • headache
  • muscle pain
  • stomach-area pain
  • diarrhea
  • vomiting
  • depression
  • trouble sleeping
  • fever
  • numbness, tingling, or burning of hands or feet

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of REYATAZ. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store REYATAZ?

REYATAZ capsules:

  • Store REYATAZ capsules at room temperature, between 68°F to 77°F (20°C to 25°C).
  • Keep capsules in a tightly closed container.

REYATAZ oral powder:

  • Store REYATAZ oral powder below 86°F (30°C).
  • Store REYATAZ oral powder in the original packet. Do not open until ready to use.
  • After REYATAZ oral powder is mixed with food or liquid it may be kept at room temperature 68°F to 86°F (20°C to 30°C) for up to 1 hour. Take REYATAZ oral powder within 1 hour after mixing with food or liquid.

Keep REYATAZ and all medicines out of the reach of children.

General information about REYATAZ

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use REYATAZ for a condition for which it was not prescribed. Do not give REYATAZ to other people, even if they have the same symptoms that you have. It may harm them. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about REYATAZ that is written for health professionals.

For more information, go to www.reyataz.com or call 1-800-321-1335.

What are the ingredients in REYATAZ?

Active ingredient: atazanavir sulfate

Inactive ingredients:

REYATAZ capsules: crospovidone, lactose monohydrate, and magnesium stearate. The capsule shells contain gelatin, FD&C Blue No. 2, titanium dioxide, black iron oxide, red iron oxide, and yellow iron oxide. The capsules are printed with ink containing shellac, titanium dioxide, FD&C Blue No. 2, isopropyl alcohol, ammonium hydroxide, propylene glycol, n-butyl alcohol, simethicone, and dehydrated alcohol.

REYATAZ oral powder: aspartame, sucrose, and orange-vanilla flavor.

This Patient Information has been approved by the U.S. Food and Drug Administration.

Instructions for Use

REYATAZ®
(RAY-ah-taz)
(atazanavir) oral powder

Read this Instructions for Use before you prepare your child's first dose of REYATAZ oral powder, each time you get a refill, and as needed. There may be new information. This information does not take the place of talking to your child's healthcare provider about their medical condition or treatment. Ask your child's healthcare provider or pharmacist if you have questions about how to mix or give a dose of REYATAZ oral powder.

Important information:

  • For more information about REYATAZ oral powder, see the Patient Information leaflet.
  • REYATAZ oral powder must be mixed with food or liquid. If REYATAZ oral powder is mixed with water, the child must eat food right after taking REYATAZ oral powder.
  • REYATAZ oral powder must be taken with ritonavir.
  • Talk with your child's healthcare provider to help decide the best schedule for giving your child REYATAZ oral powder.

Instructions for mixing REYATAZ oral powder:

REYATAZ oral powder should be mixed with food such as applesauce or yogurt, instead of a liquid (milk, infant formula, or water) in young children and infants who can take food.

  • Infants less than 6 months old and who cannot eat solid food or drink from a cup should be given REYATAZ oral powder mixed with infant formula using an oral dosing syringe.
  • REYATAZ oral powder that is mixed in infant formula or liquid should not be given using a baby bottle.

When preparing REYATAZ oral powder with either food or liquid, choose a clean, flat work surface. Place a clean paper towel on the work surface. Place the supplies you will need on the paper towel.

Wash and dry your hands before and after preparing REYATAZ oral powder.

Preparing a dose of REYATAZ oral powder mixed with food:

Before you prepare a dose of REYATAZ oral powder mixed with food, gather the following supplies:

  • paper towel
  • tablespoon
  • small clean container (such as a small cup or bowl)
  • a food such as applesauce or yogurt
  • the correct number of packets of REYATAZ oral powder needed for the prescribed dose

Step 1. Place at least 1 tablespoon of a food such as applesauce or yogurt in the small container (see Figure A).

Figure A

Place at least 1 tablespoon of a food such as applesauce or yogurt - Illustration

Step 2. Tap the packet of REYATAZ oral powder to settle the contents to the bottom of the packet (see Figure B).

Figure B

Tap the packet of REYATAZ oral powder - Illustration

Step 3. Using a clean pair of scissors, cut open the packet on the dotted line (see Figure C).

Figure C

Cut open the packet - Illustration

Step 4. Empty the contents of the packet into the small container onto the food (see Figure D).

Figure D

Empty the contents of the packet into the small container onto the food - Illustration

Repeat Steps 2 through 4 for each packet of REYATAZ oral powder needed for the total prescribed dose.

Step 5. Use a tablespoon to gently mix the powder and the food together (see Figure E).

Figure E

Gently mix the powder and the food together - Illustration

Steps 6 through 8 must be completed within 1 hour of mixing the medicine.

Step 6. Use the tablespoon or a small spoon to feed the REYATAZ oral powder and food mixture to your child. Look in your child's mouth to make sure that all of the mixture is swallowed.

Step 7. Add 1 tablespoon more of food to the empty container and gently stir to mix with any contents that may still be in the container.

Step 8. Use the tablespoon or a small spoon to feed your child the mixture, making sure your child has swallowed all of the mixture.

Step 9.Give your child ritonavir as prescribed right after taking REYATAZ oral powder.

Step 10. Wash the container and tablespoon. Allow the container and spoon to dry. Throw away the paper towel and clean the work surface.

Preparing a dose of REYATAZ oral powder mixed with liquid in a small drinking cup:

Before you prepare a dose of REYATAZ oral powder mixed with liquid in a small drinking cup, gather the following supplies:

  • paper towel
  • spoon
  • 30 milliliter (mL) medicine cup (ask your pharmacist for this). See Figure F.
  • small drinking cup
  • liquid such as milk or water
  • the correct number of packets of REYATAZ oral powder needed for the prescribed dose

Figure F

30 milliliter (mL) medicine cup - Illustration

Step 1. Using the 30 mL medicine cup, pour at least 30 mL of liquid into the small drinking cup (see Figure G).

Figure G

Pour at least 30 mL of liquid into the small drinking cup - Illustration

Step 2. Tap the packet of REYATAZ oral powder to settle the contents to the bottom of the packet (see Figure H).

Figure H

Tap the packet of REYATAZ oral powder - Illustration

Step 3. Using a clean pair of scissors, cut open the packet on the dotted line (see Figure I).

Figure I

Cut open the packet - Illustration

Step 4. Empty the contents of the packet into the small drinking cup (see Figure J).

Figure J

Empty the contents of the packet into the small drinking cup - Illustration

Repeat Steps 2 through 4 for each packet of REYATAZ oral powder needed for the total prescribed dose.

Step 5. Hold the small drinking cup with one hand. With your other hand, use the spoon to gently mix the powder and the liquid (see Figure K).

Figure K

Use the spoon to gently mix the powder and the liquid - Illustration

Steps 6 and 7 must be completed within 1 hour of mixing the medicine.

Step 6. Have your child drink all of the mixture in the small drinking cup.

Step 7. To make sure there is no mixture left in the small drinking cup add 15 mL more liquid to the small drinking cup:

  • Stir with the spoon.
  • Repeat Step 6 above.

If REYATAZ oral powder is mixed with water, your child must eat food right after taking REYATAZ oral powder.

Step 8. Give your child ritonavir as prescribed right after taking REYATAZ oral powder.

Step 9. Wash the small drinking cup, medicine cup, and spoon. Allow the small drinking cup, medicine cup, and spoon to dry. Throw away the paper towel and clean the work surface.

Preparing a dose of REYATAZ oral powder mixed with liquid infant formula using an oral dosing syringe and a small medicine cup:

Before you prepare a dose of REYATAZ oral powder mixed with infant formula using an oral dosing syringe, gather the following supplies:

  • paper towel
  • small spoon
  • 30 milliliter (mL) medicine cup (ask your pharmacist for this). See Figure L.
  • 10 mL oral dosing syringe (ask your pharmacist for this). See Figure L.
  • infant formula
  • the correct number of packets of REYATAZ oral powder needed for the prescribed dose

Figure L

30 milliliter (mL) medicine cup and 10 ml syringe Illustration

Step 1. Prepare the infant formula according to the directions on the infant formula package.

Step 2. Pour 10 mL of infant formula into the medicine cup (see Figure M).

Figure M

Pour 10 mL of infant formula into the medicine cup - Illustration

Step 3. Tap the packet of REYATAZ oral powder to settle the contents to the bottom of the packet (see Figure N).

Figure N

Tap the packet of REYATAZ oral powder - Illustration

Step 4. Using a clean pair of scissors, cut open the packet on the dotted line (see Figure O).

Figure O

Cut open the packet - Illustration

Step 5. Empty the contents of the packet into the medicine cup (see Figure P).

Figure P

Empty the contents of the packet into the medicine cup - Illustration

Repeat Steps 3 through 5 for each packet of REYATAZ oral powder needed for the total prescribed dose.

Step 6. Hold the medicine cup with one hand. With your other hand, use the small spoon to gently mix the powder and the infant formula (see Figure Q).

Figure Q

gently mix the powder and the infant formula - Illustration

Steps 7 through 9 must be completed within 1 hour of mixing the medicine.

Step 7. Draw up the powder and infant formula mixture into the oral dosing syringe as follows:

  • Check that the plunger is completely pushed into barrel of the syringe (see Figure R).

Figure R

Check that the plunger is completely pushed into barrel of the syringe - Illustration

  • Place the tip of the syringe into the powder and infant formula mixture in the medicine cup (see Figure S).

Figure S

Place the tip of the syringe into the powder and infant formula mixture - Illustration

  • Slowly pull back on the plunger and draw up 10 mL of the mixture (see Figure T).

Figure T

Draw up 10 mL of the mixture - Illustration

Step 8. Place the tip of the oral dosing syringe in your baby's mouth along the inner cheek on either the right or left side (see Figure U). Slowly push on the plunger to give your baby all of the REYATAZ oral powder and infant formula mixture.

  • Draw up any remaining mixture with the oral dosing syringe and repeat until all of the mixture has been given to the baby.

Figure U

Give your baby all of the REYATAZ oral powder and infant formula mixture - Illustration

Step 9. To make sure there is no mixture left in the medicine cup or syringe:

  • Repeat Step 1 above to add 10 mL more infant formula to the medicine cup
  • Stir with a small spoon.
  • Then repeat Steps 7 through 8 above.

To make sure that your baby gets all of the medicine, do not give REYATAZ oral powder in a baby bottle.

Step 10. Give your baby ritonavir as prescribed right after taking REYATAZ oral powder.

Step 11. Remove the plunger from the oral dosing syringe. Wash the medicine cup, spoon, and oral dosing syringe. Allow the medicine cup, spoon, and oral dosing syringe to dry. Throw away the paper towel and clean the work surface.

How should I store REYATAZ oral powder?

  • Store REYATAZ oral powder below 86°F (30°C).
  • Store REYATAZ oral powder in the original packet. Do not open until ready to use.
  • After REYATAZ oral powder is mixed with food or liquid, it may be kept at room temperature 68°F to 86°F (20°C to 30°C) for up to 1 hour. Take REYATAZ oral powder within 1 hour after mixing with food or liquid.

Keep REYATAZ oral powder and all medicines out of the reach of children.

This Instructions for Use has been approved by the U.S. Food and Drug Administration.

Last reviewed on RxList: 6/16/2014
This monograph has been modified to include the generic and brand name in many instances.

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