Rheumatoid Arthritis (RA)
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Melissa Conrad Stöppler, MD
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Catherine Burt Driver, MD
Catherine Burt Driver, MD, is board certified in internal medicine and rheumatology by the American Board of Internal Medicine. Dr. Driver is a member of the American College of Rheumatology. She currently is in active practice in the field of rheumatology in Mission Viejo, Calif., where she is a partner in Mission Internal Medical Group.
- Rheumatoid arthritis (RA) facts
- What is rheumatoid arthritis (RA)?
- Rheumatoid arthritis vs. osteoarthritis
- What are rheumatoid arthritis causes and risk factors?
- What are complications of rheumatoid arthritis?
- What are rheumatoid arthritis symptoms and signs?
- How do physicians diagnose rheumatoid arthritis?
- What are the stages of rheumatoid arthritis?
- What is the treatment for rheumatoid arthritis? What types of medications treat RA?
- "First-line" rheumatoid arthritis medications
- "Second-line" or "slow-acting" rheumatoid arthritis drugs (disease-modifying anti-rheumatic drugs or DMARDs)
- What are newer rheumatoid arthritis treatments?
- Rheumatoid arthritis diet, exercise, home remedies, and alternative medicine
- What about rheumatoid arthritis and pregnancy?
- What is the prognosis for patients with rheumatoid arthritis?
- What are tips for living with rheumatoid arthritis?
- Is it possible to prevent rheumatoid arthritis?
- What specialists treat rheumatoid arthritis (RA)?
- What new information about RA has come from the 2015 national meeting of the American College of Rheumatology?
- What research is being done on rheumatoid arthritis?
- Where can people get additional information on rheumatoid arthritis?
- Get a Grip on Rheumatoid Arthritis
- Take the RA Quiz
- Joint Friendly Exercises for RA
- Newly Diagnosed Rheumatoid Arthritis Treatment
- Rheumatoid Arthritis FAQs
- Find a local Rheumatologist in your town
Rheumatoid arthritis (RA) facts
- Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints and other areas of the body.
- Rheumatoid arthritis symptoms and signs include
- joint pain, such as in the joints of the feet, hands, and knees,
- swollen joints,
- loss of range of motion,
- tender joints,
- loss of joint function,
- stiff joints,
- joint redness,
- rheumatoid nodules,
- joint warmth,
- joint deformity, and
- symptoms and signs that affect both sides of the body (symmetry).
- Rheumatoid arthritis is a chronic disease characterized by periods of disease flares and remissions.
- In rheumatoid arthritis, multiple joints are usually, but not always, affected in a symmetrical pattern.
- Chronic inflammation of rheumatoid arthritis can cause permanent joint destruction and deformity.
- Damage to joints can occur early and does not always correlate with the severity of RA symptoms.
- The "rheumatoid factor" is an antibody that can be found in the blood of 80% of people with rheumatoid arthritis. Rheumatoid factor is detected in a simple blood test. Possible risk factors for developing rheumatoid arthritis include genetic background, smoking, silica inhalation, periodontal disease, and microbes in the bowels (gut bacteria).
- There is no cure for RA. The treatment of rheumatoid arthritis optimally involves a combination of patient education, rest and exercise, joint protection, medications, and occasionally surgery.
- Medications used in the treatment of rheumatoid arthritis include NSAIDs, DMARDs, TNF alpha inhibitors, IL-6 inhibitors, T-cell activation inhibitors, B-cell depletors, JAK inhibitors, immunosuppressants, and steroids.
- Early RA treatment results in a better prognosis.
- Rheumatoid arthritis can affect people of all ages. The cause of rheumatoid arthritis is not known.
What is rheumatoid arthritis (RA)?
Rheumatoid arthritis definition
Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Autoimmune diseases are illnesses that occur when the body's tissues are mistakenly attacked by their own immune system. The immune system contains a complex organization of cells and antibodies designed normally to "seek and destroy" invaders of the body, particularly infections. Patients with autoimmune diseases have antibodies and immune cells in their blood that target their own body tissues, where they can be associated with inflammation. While inflammation of the tissue around the joints and inflammatory arthritis are characteristic features of rheumatoid arthritis, the disease can also cause inflammation and injury in other organs in the body. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. Rheumatoid arthritis is a classic rheumatic disease. Rheumatoid arthritis that begins in people under 16 years of age is referred to as juvenile idiopathic arthritis or JIA (formerly juvenile rheumatoid arthritis or JRA).
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