"Nov. 6, 2012 -- The FDA has approved Pfizer's Xeljanz (tofacitinib), a first-of-its-kind treatment for rheumatoid arthritis.
Xeljanz is approved for use by patients not helped by methotrexate, the usual first treatment for RA. It's a "...
Rheumatrex Patient Information including If I Miss a Dose
In this Article
- What is methotrexate (Rheumatrex)?
- What are the possible side effects of methotrexate (Rheumatrex)?
- What is the most important information I should know about methotrexate (Rheumatrex)?
- What should I discuss with my healthcare provider before taking methotrexate (Rheumatrex)?
- How should I take methotrexate (Rheumatrex)?
- What happens if I miss a dose (Rheumatrex)?
- What happens if I overdose (Rheumatrex)?
- What should I avoid while taking methotrexate (Rheumatrex)?
- What other drugs will affect methotrexate (Rheumatrex)?
- Where can I get more information?
What happens if I miss a dose (Rheumatrex)?
Call your doctor if you miss a dose of methotrexate.
What happens if I overdose (Rheumatrex)?
Seek emergency medical attention if you think you have used too much of this medicine. An overdose of methotrexate can be fatal.
Overdose symptoms may include pale skin, easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, coughing up blood or vomit that looks like coffee grounds, and urinating less than usual or not at all.
What should I avoid while taking methotrexate (Rheumatrex)?
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds), especially if you are being treated for psoriasis. Methotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen.
Avoid drinking alcohol while taking methotrexate.
What other drugs will affect methotrexate (Rheumatrex)?
Before taking methotrexate, tell your doctor if you are using any of the following drugs:
- azathioprine (Imuran);
- chloramphenicol (Chloromycetin);
- hydroxychloroquine (Plaquenil, Quineprox);
- retinol, tretinoin (Retin-A), isotretinoin (Accutane);
- steroids (prednisone and others);
- sulfa drugs such as Azulfidine, Bactrim, or Septra;
- phenytoin (Dilantin);
- probenecid (Benemid);
- tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
- theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur);
- gold treatments such as auranofin (Ridura);
- oral diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glipizide (Glucotrol), glimepiride (Amaryl), or tolbutamide (Orinase);
- a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others;
- medicines that reduce stomach acid, such as esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), or rabeprazole (Aciphex);
- NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others; or
- salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others.
This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about methotrexate.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Rheumatrex Information
- Rheumatrex Drug Interactions Center: methotrexate sodium oral
- Rheumatrex Side Effects Center
- Rheumatrex FDA Approved Prescribing Information including Dosage
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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